By contributing to noninvasive molecular imaging and radioguided surgery, nuclear medicine has been instrumental in the realization of precision medicine. During the last decade, it has also become apparent that nuclear medicine (e.g., in the form of bimodal/hybrid tracers) can help to empower fluorescence-guided surgery. More specifically, when using hybrid tracers, lesions can be noninvasively identified and localized with a high sensitivity and precision (guided by the radioisotope) and ultimately resected under real-time optical guidance (fluorescent dye). This topical review discusses early clinical successes, preclinical directions, and key aspects that could have an impact on the future of this field.

中文翻译：

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趋势：放射性和荧光双峰/混合示踪剂作为手术指导的多路复用解决方案。

通过为无创分子成像和放射引导手术做出贡献，核医学已在精密医学的实现中发挥了重要作用。在过去的十年中，核医学（例如，以双峰/混合示踪剂的形式）可以帮助增强荧光引导的手术，这一点也变得很明显。更具体地说，当使用混合示踪剂时，可以以高灵敏度和精确度（由放射性同位素引导）以无创方式识别和定位病变，并最终在实时光学引导下（荧光染料）切除。本主题综述讨论了可能会对该领域的未来产生影响的早期临床成功，临床前指导以及关键方面。