We report on the development of the PennPET Explorer whole-body imager. Methods: The PennPET Explorer is a multiring system designed with a long axial field of view. The imager is scalable and comprises multiple 22.9-cm-long ring segments, each with 18 detector modules based on a commercial digital silicon photomultiplier. A prototype 3-segment imager has been completed and tested with an active 64-cm axial field of view. Results: The instrument design is described, and its physical performance measurements are presented. These include sensitivity of 55 kcps/MBq, spatial resolution of 4.0 mm, energy resolution of 12%, timing resolution of 256 ps, and a noise-equivalent count rate above 1,000 kcps beyond 30 kBq/mL. After an evaluation of lesion torso phantoms to characterize quantitative accuracy, human studies were performed on healthy volunteers. Conclusion: The physical performance measurements validated the system design and led to high-quality human studies.

中文翻译：

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PennPET Explorer：全身成像仪的设计和初步性能。

我们报告了 PennPET Explorer 全身成像仪的开发情况。方法：PennPET Explorer 是一个设计有长轴向视野的多环系统。该成像器是可扩展的，包括多个 22.9 厘米长的环段，每个环段有 18 个基于商用数字硅光电倍增管的检测器模块。原型 3 段成像器已经完成，并使用 64 厘米的活动轴向视场进行了测试。结果：描述了仪器设计，并介绍了其物理性能测量值。其中包括 55 kcps/MBq 的灵敏度、4.0 mm 的空间分辨率、12% 的能量分辨率、256 ps 的时间分辨率以及超过 30 kBq/mL 的超过 1,000 kcps 的噪声等效计数率。在对损伤躯干模型进行评估以表征定量准确性后，对健康志愿者进行了人体研究。