Present work portray the synthesis of four new tridentate Schiff base ligand transition metal chelates having 1,2,4-triazine and 1,4-Naphthoquinone as a potential drug candidate, with composition ML₂, where M=Co(II), Ni(II), Cu(II) and Zn(II); L = 4-(2-(5,6-diphenyl-1,2,4-triazin-3-yl)hydrazono)-3-hydroxynaphthalene-1(4H)-one (DTN). Credible structure of the synthesized compounds was investigated using different techniques like elemental analysis, molar conductance, mass spectra, magnetic susceptibility, UV–Visible, IR, NMR and TGA. The results were unfailing with tridentate nature of the ligand and octahedral geometry of metal chelates. Thermal scrutiny of the synthesized complexes exemplified absence of coordinated water molecules, decomposition patterns of the complexes and their stabilities. Furthermore, redox behaviour of the synthesized compounds was examined by cyclic voltammetry in DMSO solution. Antimicrobial screening tests played a pivotal role in displaying the presence of metal ion in the ligand system. Chemical nuclease activity was investigated to study the DNA cleavage activities of the synthesized compounds and effectual cleavage was revealed by Co(II) and Cu(II) metal chelates of DTN.

Graphic Abstract

中文翻译：

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三齿（NNO）1,2,4-三嗪席夫碱的金属螯合物：合成，理化研究和药理筛选

目前的工作描绘了合成新的具有1,2,4-三嗪和1,4-萘醌作为潜在候选药物的三齿Schiff碱配体过渡金属螯合物的组成，成分为ML ₂，其中M = Co（II），Ni（ II），Cu（II）和Zn（II）；L = 4-（2-（5,6-二苯基-1,2,4-三嗪-3-基）肼基）-3-羟基萘-1（4 H）-一（DTN）。使用不同的技术，例如元素分析，摩尔电导，质谱，磁化率，UV-Visible，IR，NMR和TGA，研究了合成化合物的可信结构。结果与配体的三齿性质和金属螯合物的八面体几何形状一致。合成配合物的热检查表明不存在配位水分子，配合物的分解模式及其稳定性。此外，通过循环伏安法在DMSO溶液中检查了合成化合物的氧化还原行为。抗菌筛选测试在显示配体系统中金属离子的存在方面起着关键作用。

图形摘要