Poly (n-butylcyanocrylate) nanocapsules were obtained by interfacial polymerization from a water-in-oil microemulsion. The latter was composed of pharmaceutically acceptable excipients such as Labrafac lipophile WL 1349 (oil), Plurol oleique CC497 (surfactant), and Labrasol (co-surfactant) and was able to incorporate 20% aqueous phase. Pure n-butylcyanoacrylate monomer (without any dilution in a halogenated solvent) was added to the microemulsion in order to obtain an oily suspension of biocompatible and biodegradable aqueous core nanocapsules. Finally, in order to provide a direct evidence of the presence of water within the nanocapsules, a mass balance and nuclear magnetic resonance analysis were performed. The results showed that the presence of water and transmission electronic microscopy confirmed a hybrid structure of the final nanosystem, between a genuine nanocapsule and a matrix system: a nanosystem with multicavities filled with water. Graphical abstract

中文翻译：

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聚（氰基丙烯酸烷基酯）纳米粒子中含水储层的鉴定

聚（正丁基氰基丙烯酸酯）纳米胶囊是通过界面聚合从油包水微乳液中获得的。后者由药学上可接受的赋形剂组成，例如 Labrafac 亲脂性 WL 1349（油）、Plurol oleique CC497（表面活性剂）和 Labrasol（辅助表面活性剂），并且能够掺入 20% 的水相。将纯的氰基丙烯酸正丁酯单体（没有在卤化溶剂中进行任何稀释）添加到微乳液中以获得生物相容性和可生物降解的水性核心纳米胶囊的油性悬浮液。最后，为了提供纳米胶囊内存在水的直接证据，进行了质量平衡和核磁共振分析。结果表明，水和透射电子显微镜的存在证实了最终纳米系统的混合结构，在真正的纳米胶囊和基质系统之间：一个充满水的多腔纳米系统。图形概要