Entanglements of strings are regularly encountered on the macroscale yet rarely utilized in nanoscale construction. Here, we report highly entangled peptide-mimic structures created through folding and assembly of silver(I) ions and a triglycine ligand (L). The highly flexible triglycine strand assembled into a septafoil knot ([Ag⋅L]₇) and its eight-crossing link analog ([Ag⋅L]₈), both of which were formed for the first time by chemical synthesis. The two structures result from circular oligomerization of the same 1-crossing Ag⋅L motif. We also obtained poly[n]catenane [Ag⋅L]_n from a topologically isomeric 2-crossing motif. Our observations reveal that dynamic linkages of short peptides enable easy access to knotted structures, which are restricted in protein structures because of the entropic (and/or kinetic) disadvantage of self-threading processes in long peptide chains, with remarkable stereoselectivity in the self-assembly process.

字符串经常在宏观上遇到缠结，但很少用于纳米级构造中。在这里，我们报告高度折叠的肽模拟结构，通过折叠和组装银（I）离子和三甘氨酸配体（L）产生。高柔性的三甘氨酸链组装成七叶形结（[Ag⋅L] ₇）和它的八个交叉连接类似物（[Ag⋅L] ₈），两者都是通过化学合成首次形成的。这两个结构是由相同的1个交联的Ag⋅L基序的圆形低聚产生的。我们还获得了聚[ n ] catenane [Ag⋅L] _n来自拓扑异构的2交点基序。我们的观察结果表明，短肽的动态键合使得易于进入打结的结构，而这种结构由于长肽链中自穿线过程的熵（和/或动力学）劣势而在蛋白质结构中受到限制，并且在自身结构中具有显着的立体选择性。组装过程。