Heart regeneration, a relatively new field of biology, is one of the most active and controversial areas of biomedical research. The potential impact of successful human heart regeneration therapeutics cannot be overstated, given the magnitude and prognosis of heart failure. However, the regenerative process is highly complex, and premature claims of successful heart regeneration have both fueled interest and created controversy. The field as a whole is now in the process of course correction, and a clearer picture is beginning to emerge. Despite the challenges, fundamental principles in developmental biology have provided a framework for hypothesis-driven approaches toward the ultimate goal of adult heart regeneration and repair. In this review, we discuss the current state of the field and outline the potential paths forward toward regenerating the human myocardium.

中文翻译：

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朝着人类心脏再生的目标迈进。

心脏再生是一个相对较新的生物学领域，是生物医学研究中最活跃和最具争议的领域之一。考虑到心力衰竭的严重程度和预后，成功的人类心脏再生疗法的潜在影响不可低估。然而，再生过程非常复杂，过早主张成功进行心脏再生既引起了人们的兴趣，也引起了争议。整个领域现在正在进行路线校正，并且开始出现更清晰的画面。尽管存在挑战，但发育生物学的基本原理为实现成人心脏再生和修复的最终目标提供了由假设驱动的方法的框架。在这篇评论中，