Alkylarylation of N-allylbenzamides and N-allylanilines with simple ethers for the direct construction of ether substituted dihydroisoquinolinones and indolines.,Organic & Biomolecular Chemistry

当前位置： X-MOL 学术 › Org. Biomol. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Alkylarylation of N-allylbenzamides and N-allylanilines with simple ethers for the direct construction of ether substituted dihydroisoquinolinones and indolines.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-01-10 , DOI: 10.1039/c9ob02565k
Yiting Li ₁ , Song Sun ₁ , Jiang Cheng ₁ , Jin-Tao Yu ₁

Affiliation

A radical-initiated cascade addition and cyclization of N-allylbenzamides with simple ethers to construct ether-substituted dihydroisoquinolinones was performed in the presence of CuI. The cleavage of the sp3 C-H bond in ether and the sp2 C-H bond in phenyl was involved in this reaction. Moreover, the arylalkylation of N-allylanilines was also realized under similar reaction conditions, providing ether-functionalized indolines in good to moderate yields.

中文翻译：

N-烯丙苯甲酰胺和N-烯丙胺与简单醚的烷基芳基化反应，可直接构建醚取代的二氢异喹啉酮和二氢吲哚。

在CuI的存在下，进行自由基引发的N-烯丙基苯甲酰胺的级联加成反应，并与简单的醚环化，以构建醚取代的二氢异喹啉酮。该反应涉及醚中sp3 CH键的裂解和苯基中sp2 CH键的裂解。而且，在类似的反应条件下也可以实现N-烯丙啉的芳烷基化，从而以良好至中等的产率提供醚官能化的二氢吲哚。

更新日期：2020-02-10

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11