para-Selective copper-catalyzed C(sp2)-H amidation/dimerization of anilides via a radical pathway.,Chemical Communications

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para-Selective copper-catalyzed C(sp2)-H amidation/dimerization of anilides via a radical pathway.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-01-13 , DOI: 10.1039/c9cc09824k
Amol B Viveki ₁ , Dnyaneshwar N Garad ₁ , Rajesh G Gonnade ₂ , Santosh B Mhaske ₁

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Copper-catalyzed amidation/dimerization of anilides via regioselective C(sp2)-H functionalization is achieved. The para-selective amidation is accomplished on the anilide aromatic ring via a radical pathway leading to C-N bond formation in the presence of ammonium persulfate as a radical source/oxidant for the copper catalyst. The developed protocol tolerates a wide range of anilide substrates. The regioselectivity is confirmed by single-crystal X-ray studies.

中文翻译：

经由自由基途径的苯甲酸酯的对位选择性铜催化的C（sp2）-H酰胺化/二聚。

通过区域选择性的C（sp2）-H功能化实现了铜催化的苯甲酰胺的酰胺化/二聚化。在过硫酸铵作为铜催化剂的自由基源/氧化剂的情况下，通过导致CN键形成的自由基途径，在苯胺芳环上完成对选择酰胺化。所开发的方案可耐受多种苯胺基体。区域选择性通过单晶X射线研究证实。

更新日期：2020-01-13

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