Confounding effect of blood volume and body mass index on blood neurofilament light chain levels.,Annals of Clinical and Translational Neurology

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Confounding effect of blood volume and body mass index on blood neurofilament light chain levels.
Annals of Clinical and Translational Neurology ( IF 5.3 ) Pub Date : 2020-01-01 , DOI: 10.1002/acn3.50972
Ali Manouchehrinia _{1,

2} , Fredrik Piehl _{1,

2} , Jan Hillert ₁ , Jens Kuhle ₃ , Lars Alfredsson ₄ , Tomas Olsson _{1,

2} , Ingrid Kockum _{1,

2}

Affiliation

Blood Neurofilament light chain (NfL) has been suggested as a promising biomarker in several neurological conditions. Since blood NfL is the consequence of leaked NfL from the cerebrospinal fluid, differences in individuals’ Body Mass Index (BMI) or blood volume (BV) might affect its correlation to other biomarkers and disease outcomes. Here, we investigated the correlation between plasma NfL, BMI, and BV in 662 controls and 2,586 multiple sclerosis cases. We found a significant negative correlation between plasma NfL, BMI/BV in both groups. Our results highlight the potential confounding effect of BMI/BV on associations between blood NfL and disease outcomes.

中文翻译：

血容量和体重指数对血液神经丝轻链水平的混杂影响。

血液神经丝轻链（NfL）已被建议在几种神经系统疾病中作为有前途的生物标志物。由于血液NfL是从脑脊液中泄漏NfL的结果，因此个体的体重指数（BMI）或血容量（BV）的差异可能会影响其与其他生物标记物和疾病结局的相关性。在这里，我们调查了662名对照和2,586名多发性硬化症患者血浆NfL，BMI和BV之间的相关性。我们发现两组血浆NfL，BMI / BV之间存在显着的负相关。我们的结果强调了BMI / BV对血液NfL与疾病结局之间的潜在混杂影响。

更新日期：2020-01-01

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