LINC00311 promotes cancer stem-like properties by targeting miR-330-5p/TLR4 pathway in human papillary thyroid cancer.,Cancer Medicine

当前位置： X-MOL 学术 › Cancer Med. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

LINC00311 promotes cancer stem-like properties by targeting miR-330-5p/TLR4 pathway in human papillary thyroid cancer.
Cancer Medicine ( IF 2.9 ) Pub Date : 2020-01-02 , DOI: 10.1002/cam4.2815
Yu Gao ₁ , Fan Wang ₁ , Li Zhang ₁ , Mei Kang ₁ , Liyang Zhu ₁ , Lei Xu ₁ , Wei Liang ₁ , Wei Zhang ₂

Affiliation

Growing evidence has suggested that long noncoding RNAs (lncRNAs) play an essential role in the progression of papillary thyroid cancer (PTC). LncRNA LINC00311 was found to be able to regulate many cellular process in several diseases. However, the function and regulatory mechanism of LINC00311 remains unclear in PTC. In the present study, the results showed that the expression of LINC00311 was upregulated in PTC tissues and cells. Furthermore, knockdown of LINC00311 dramatically suppressed spheroid formation, proliferation, migration, and invasion in PTC cells in vitro. Mechanistic investigations revealed that LINC00311 was negatively correlated with the expression of miR-330-5p, meanwhile, TLR4 was a direct target of miR-330-5p. In addition, rescue assays further determined that LINC00311 contributed to the progression of PTC through regulating TLR4 expression. Taken together, these findings indicated that LINC00311 could promote cancer stem-like properties by targeting miR-330-5p/TLR4 pathway in PTC.

中文翻译：

LINC00311 通过靶向人乳头状甲状腺癌中的 miR-330-5p/TLR4 通路促进癌症干细胞样特性。

越来越多的证据表明，长链非编码 RNA (lncRNA) 在甲状腺乳头状癌 (PTC) 的进展中发挥着重要作用。LncRNA LINC00311 被发现能够调节多种疾病中的许多细胞过程。然而，LINC00311的功能和调控机制在PTC中仍不清楚。在本研究中，结果显示 LINC00311 的表达在 PTC 组织和细胞中上调。此外，LINC00311 的敲低显着抑制了体外 PTC 细胞的球体形成、增殖、迁移和侵袭。机制研究表明，LINC00311 与 miR-330-5p 的表达呈负相关，同时，TLR4 是 miR-330-5p 的直接靶标。此外，救援分析进一步确定 LINC00311 通过调节 TLR4 表达促进 PTC 的进展。总之，这些发现表明 LINC00311 可以通过靶向 PTC 中的 miR-330-5p/TLR4 通路来促进癌症干细胞样特性。

更新日期：2020-01-02

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11