Senescent cells have been suspected, because of their secretory phenotype (SASP or Senescence Associated Secretory Profile), to contribute to the extension of the chronic inflammatory condition leading to unhealthy aging processes. AISA (Anti-Inflammatory Senescence Actives) monoterpens have been characterized as possessing anti-inflammatory capacities in young cells submitted to pro-inflammatory cytokine stimulation. They have also been demonstrated to have the ability to act on senescent cells, reversing their characteristic pro-inflammatory phenotype. This is due to the fact that AISA act on the cytoskeleton scaffold of cells where actin polymerization induces the expression of adhesion molecules, fueling the infernal inflammatory loop. In comparison to other isoprenoid actives in degenerative diseases, the AISA monoterpene adds a mood-modulating capacity inducing the vagus nerve tone and its potent anti-inflammatory role.

中文翻译：

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AISA可以控制SASP的炎症状态。

由于它们的分泌表型（SASP或衰老相关分泌概况），人们已经怀疑衰老细胞有助于延长慢性炎症，导致不健康的衰老过程。AISA（抗炎衰老活性物质）单萜的特征在于，在受到促炎性细胞因子刺激的年轻细胞中具有抗炎能力。还已经证明它们具有作用于衰老细胞的能力，可以逆转其特征性的促炎表型。这是由于AISA作用于细胞的细胞骨架支架的事实，其中肌动蛋白的聚合反应诱导粘附分子的表达，助长了地狱炎性循环。与退化性疾病中的其他类异戊二烯活性物质相比，