To further explore the wonder of nano technology in drug delivery system, the combination of micelles and mesoporous silica was conducted for delivering poorly water soluble nifedipine (NFP). Double-nano silica xerogel (DN-SX) with both micelles and nanopores was prepared and silica xerogel with only nanopores (SN-SX) was made for comparison. Characteristics of DN-SX and SN-SX, including morphology, porous structure and crystalline state were investigated and pharmaceutical performances of drug loaded carriers were studied. The micelles in DN-SX contributed to achieve larger mesopores and enhanced NFP dissolution better than SN-SX. How responses of drug release amount and reduced drug release amount reacted as changing each influencing factor was elucidated by Box–Behnken experimental design. With the DN-SX obtained by optimization, in vivo pharmacokinetic study result demonstrated that the relative bioavailability of NFP loaded DN-SX and NFP loaded SN-SX were 216.84% and 161.14%, respectively. Therefore, the optimized DN-SX with double-nano structure was of great value for designing poorly water soluble drug delivery system.

为了进一步探索纳米技术在药物输送系统中的应用，胶束和中孔二氧化硅的组合用于输送水溶性差的硝苯地平（NFP）。制备具有胶束和纳米孔的双纳米二氧化硅干凝胶（DN-SX），并制备仅具有纳米孔的二氧化硅干凝胶（SN-SX）进行比较。研究了DN-SX和SN-SX的形态，多孔结构和结晶状态，并研究了载药载体的药理性能。DN-SX中的胶束比SN-SX更好地实现了更大的中孔并增强了NFP的溶解性。Box–Behnken实验设计阐明了随着各种影响因素的变化，药物释放量和减少的药物释放量如何反应。通过优化获得的DN-SX，体内药代动力学研究结果表明，NFP负载的DN-SX和NFP负载的SN-SX的相对生物利用度分别为216.84％和161.14％。因此，优化的具有双纳米结构的DN-SX对于设计水溶性差的药物递送系统具有重要的价值。