The number of people affected by heart disease such as coronary artery disease and myocardial infarction increases at an alarming rate each year. Currently, the methods to treat these diseases are restricted to lifestyle change, pharmaceuticals, and eventually heart transplant if the condition is severe enough. While these treatment options are the standard for caring for patients who suffer from heart disease, limited regenerative ability of the heart restricts the effectiveness of treatment and may lead to other heart‐related health problems in the future. Because of the increasing need for more effective therapeutic technologies for treating diseased heart tissue, cardiac patches are now a large focus for researchers. The cardiac patches are designed to be integrated into the patients' natural tissue to introduce mechanical support and healing to the damaged areas. As a promising alternative, synthetic biodegradable polymer based biomaterials can be easily manipulated to customize material properties, as well as possess certain desired characteristics for cardiac patch use. This comprehensive review summarizes recent works on synthetic biodegradable cardiac patches implanted into infarcted animal models. In addition, this review describes the basic requirements that should be met for cardiac patch development, and discusses the inspirations to designing new biomaterials and technologies for cardiac patches.

中文翻译：

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基于可生物降解合成聚合物的心脏贴片的当前进展。

冠状动脉疾病和心肌梗塞等心脏病的人数每年都在以惊人的速度增加。目前，治疗这些疾病的方法仅限于改变生活方式、药物和最终在病情足够严重时进行心脏移植。虽然这些治疗方案是照顾患有心脏病的患者的标准，但心脏的有限再生能力限制了治疗的有效性，并可能在未来导致其他与心脏相关的健康问题。由于越来越需要更有效的治疗技术来治疗患病的心脏组织，因此心脏贴片现在是研究人员的一大重点。心脏贴片旨在融入患者的 天然组织为受损区域引入机械支撑和愈合。作为一种有前景的替代方案，基于合成的可生物降解聚合物的生物材料可以很容易地进行操作以定制材料特性，并具有某些所需的心脏贴片使用特性。这篇综合综述总结了植入梗塞动物模型的合成可生物降解心脏补片的最新工作。此外，这篇综述描述了心脏补片开发应满足的基本要求，并讨论了设计新的心脏补片生物材料和技术的灵感。以及具有心脏贴片使用所需的某些特性。这篇综合综述总结了植入梗塞动物模型的合成可生物降解心脏补片的最新工作。此外，这篇综述描述了心脏补片开发应满足的基本要求，并讨论了设计新的心脏补片生物材料和技术的灵感。以及具有心脏贴片使用所需的某些特性。这篇综合综述总结了植入梗塞动物模型的合成可生物降解心脏补片的最新工作。此外，这篇综述描述了心脏补片开发应满足的基本要求，并讨论了设计新的心脏补片生物材料和技术的灵感。