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Linoleic acid-good or bad for the brain?
npj Science of Food ( IF 6.3 ) Pub Date : 2020-01-02 , DOI: 10.1038/s41538-019-0061-9
Ameer Y Taha 1
Affiliation  

Increased intake of omega-6 rich plant oils such as soybean and corn oil over the past few decades has inadvertently tripled the amount of n-6 linoleic acid (LA, 18:2n-6) in the diet. Although LA is nutritionally "essential", very little is known about how it affects the brain when present in excess. This review provides an overview on the metabolism of LA by the brain and the effects of excess dietary LA intake on brain function. Pre-clinical evidence suggests that excess dietary LA increases the brain's vulnerability to inflammation and likely acts via its oxidized metabolites. In humans, excess maternal LA intake has been linked to a typical neurodevelopment, but underlying mechanisms are unknown. It is concluded that excess dietary LA may adversely affect the brain. The potential neuroprotective role of reducing dietary LA merits clinical evaluation in future studies.

中文翻译:

亚油酸对大脑好还是坏?

在过去的几十年中,富含omega-6的植物油(例如大豆和玉米油)的摄入量增加,无意中使饮食中的n-6亚油酸(LA,18:2n-6)的量增加了三倍。尽管LA在营养上是“必需的”,但对过量存在时它如何影响大脑的知之甚少。这篇综述概述了大脑对LA的代谢以及饮食中过量摄入LA对脑功能的影响。临床前证据表明,饮食中过量的LA会增加大脑对炎症的脆弱性,并可能通过其氧化代谢产物起作用。在人类中,孕妇的过量摄入与典型的神经发育有关,但其潜在机制尚不清楚。结论是过量的饮食LA可能会对大脑产生不利影响。
更新日期:2020-01-02
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