Aza‐o‐quinone methides and their conjugated acids are reactive drug metabolites that might react with nucleophilic sites of DNAs and proteins to cause cancer or immune responses, and their reactivity with water is the key information to judge if these metabolites are harmful in living systems. For the first time, aza‐o‐quinone methide (1) and its conjugated acid (2) are observed by laser flash photolysis, and their reactivity, stability and acidity in water are determined.

中文翻译：

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氮杂-邻-奎宁甲基化物及其共轭酸：反应性，稳定性和酸度。

氮杂o醌甲基化物及其共轭酸是可能与DNA和蛋白质的亲核位点发生反应以引起癌症或免疫反应的活性药物代谢物，其与水的反应性是判断这些代谢物是否对生命系统有害的关键信息。首次，氮杂ö -quinone甲基化物（1）和它的共轭酸（2）通过激光闪光光解观察到的，和它们的反应性，稳定性和酸性水被确定。