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The effects of resveratrol intake on weight loss: a systematic review and meta-analysis of randomized controlled trials.
Critical Reviews in Food Science and Nutrition ( IF 10.2 ) Pub Date : 2018-11-13 , DOI: 10.1080/10408398.2018.1529654
Reza Tabrizi 1 , Omid Reza Tamtaji 2, 3 , Kamran B Lankarani 4 , Maryam Akbari 1 , Ehsan Dadgostar 3 , Mohammad Hossein Dabbaghmanesh 5 , Fariba Kolahdooz 6 , Amir Shamshirian 7 , Mansooreh Momen-Heravi 8, 9 , Zatollah Asemi 10
Affiliation  

This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of resveratrol intake on weight loss. We searched the following databases until July 2018: MEDLINE, EMBASE, Web of Science and Cochrane Central Register of Controlled Trials. Data were pooled using the inverse variance method and expressed as standardized mean difference (SMD) with 95% confidence intervals (95% CI). Out of 831 reports, 36 RCTs were eligible for including to our meta-analysis. The pooled results, using random-effects model showed that resveratrol supplementation significantly decreased body weight (SMD = -0.17; 95% CI, -0.33, -0.01; P = 0.03; I2: 62.6), body mass index (BMI) (SMD = -0.20; 95% CI, -0.35, -0.05; P = 0.01; I2: 60.6), fat mass (SMD = -0.32; 95% CI, -0.62, -0.03; P = 0.03; I2: 77.9) and waist circumference (WC) (SMD = -0.42; 95% CI, -0.68, -0.16; P = 0.001; I2: 75.2), and significantly increased lean mass (SMD = 1.21; 95% CI, 0.75, 1.67; P < 0.001; I2: 87.6). We found no significant effect of resveratrol administration on leptin (SMD = -0.20; 95% CI, -0.68, 0.27; P = 0.40; I2: 85.3) and adiponectin levels (SMD = 0.08; 95% CI, -0.39, 0.55; P = 0.74; I2: 91.0). Resveratrol supplementation significantly decreased body weight in obese patients (SMD -0.43; 95% CI, -0.60, -0.26) compared with other diseases (SMD 0.02; 95% CI, -0.29, 0.33), and type 2 diabetes mellitus (SMD -0.17; 95% CI, -0.37, 0.02). Overall, the current meta-analysis demonstrated that resveratrol intake significantly reduced weight, BMI, WC and fat mass, and significantly increased lean mass, but did not affect leptin and adiponectin levels.

中文翻译:

白藜芦醇摄入量对减肥的影响:随机对照试验的系统评价和荟萃分析。

对随机对照试验(RCT)进行了系统的回顾和荟萃分析,以总结白藜芦醇摄入量对减肥的影响。我们搜索了直到2018年7月的以下数据库:MEDLINE,EMBASE,Web of Science和Cochrane对照试验中央注册簿。使用逆方差方法合并数据,并以具有95%置信区间(95%CI)的标准化均值差(SMD)表示。在831份报告中,有36项RCT有资格纳入我们的荟萃分析。使用随机效应模型的汇总结果显示,补充白藜芦醇可以显着降低体重(SMD = -0.17; 95%CI,-0.33,-0.01; P = 0.03; I2:62.6),体重指数(BMI)(SMD) = -0.20; 95%CI,-0.35,-0.05; P = 0.01; I2:60.6),脂肪量(SMD = -0.32; 95%CI,-0.62,-0.03; P = 0.03; I2:77。9)和腰围(WC)(SMD = -0.42; 95%CI,-0.68,-0.16; P = 0.001; I2:75.2),并且瘦体重显着增加(SMD = 1.21; 95%CI,0.75,1.67 ; P <0.001; I2:87.6)。我们发现白藜芦醇对瘦素(SMD = -0.20; 95%CI,-0.68,0.27; P = 0.40; I2:85.3)和脂联素水平(SMD = 0.08; 95%CI,-0.39,0.55; P = 0.74; I2:91.0)。与其他疾病(SMD 0.02; 95%CI,-0.29,0.33)和2型糖尿病(SMD- 0.17; 95%CI,-0.37,0.02)。总体而言,当前的荟萃分析表明,白藜芦醇的摄入量显着降低了体重,BMI,WC和脂肪量,并且显着增加了瘦肉量,但并未影响瘦素和脂联素的水平。42; 95%CI,-0.68,-0.16;P = 0.001;I2:75.2),并显着增加了瘦肉质量(SMD = 1.21; 95%CI,0.75、1.67; P <0.001; I2:87.6)。我们发现白藜芦醇对瘦素(SMD = -0.20; 95%CI,-0.68,0.27; P = 0.40; I2:85.3)和脂联素水平(SMD = 0.08; 95%CI,-0.39,0.55; P = 0.74; I2:91.0)。与其他疾病(SMD 0.02; 95%CI,-0.29,0.33)和2型糖尿病(SMD- 0.17; 95%CI,-0.37,0.02)。总体而言,当前的荟萃分析表明,白藜芦醇的摄入量显着降低了体重,BMI,WC和脂肪量,并且显着增加了瘦肉量,但并未影响瘦素和脂联素的水平。42; 95%CI,-0.68,-0.16;P = 0.001;I2:75.2),并显着增加了瘦肉质量(SMD = 1.21; 95%CI,0.75、1.67; P <0.001; I2:87.6)。我们发现白藜芦醇对瘦素(SMD = -0.20; 95%CI,-0.68,0.27; P = 0.40; I2:85.3)和脂联素水平(SMD = 0.08; 95%CI,-0.39,0.55; P = 0.74; I2:91.0)。与其他疾病(SMD 0.02; 95%CI,-0.29,0.33)和2型糖尿病(SMD- 0.17; 95%CI,-0.37,0.02)。总体而言,当前的荟萃分析表明,白藜芦醇的摄入量显着降低了体重,BMI,WC和脂肪量,并且显着增加了瘦肉量,但并未影响瘦素和脂联素的水平。并显着增加了瘦肉质量(SMD = 1.21; 95%CI,0.75,1.67; P <0.001; I2:87.6)。我们发现白藜芦醇对瘦素(SMD = -0.20; 95%CI,-0.68,0.27; P = 0.40; I2:85.3)和脂联素水平(SMD = 0.08; 95%CI,-0.39,0.55; P = 0.74; I2:91.0)。与其他疾病(SMD 0.02; 95%CI,-0.29,0.33)和2型糖尿病(SMD- 0.17; 95%CI,-0.37,0.02)。总体而言,当前的荟萃分析表明,白藜芦醇的摄入量显着降低了体重,BMI,WC和脂肪量,并且显着增加了瘦肉量,但并未影响瘦素和脂联素的水平。并显着增加了瘦肉质量(SMD = 1.21; 95%CI,0.75,1.67; P <0.001; I2:87.6)。我们发现白藜芦醇对瘦素(SMD = -0.20; 95%CI,-0.68,0.27; P = 0.40; I2:85.3)和脂联素水平(SMD = 0.08; 95%CI,-0.39,0.55; P = 0.74; I2:91.0)。与其他疾病(SMD 0.02; 95%CI,-0.29,0.33)和2型糖尿病(SMD- 0.17; 95%CI,-0.37,0.02)。总体而言,当前的荟萃分析表明,白藜芦醇的摄入量显着降低了体重,BMI,WC和脂肪量,并且显着增加了瘦肉量,但并未影响瘦素和脂联素的水平。我们发现白藜芦醇对瘦素(SMD = -0.20; 95%CI,-0.68,0.27; P = 0.40; I2:85.3)和脂联素水平(SMD = 0.08; 95%CI,-0.39,0.55; P = 0.74; I2:91.0)。与其他疾病(SMD 0.02; 95%CI,-0.29,0.33)和2型糖尿病(SMD- 0.17; 95%CI,-0.37,0.02)。总体而言,当前的荟萃分析表明,白藜芦醇的摄入量显着降低了体重,BMI,WC和脂肪量,并且显着增加了瘦肉量,但并未影响瘦素和脂联素的水平。我们发现白藜芦醇对瘦素(SMD = -0.20; 95%CI,-0.68,0.27; P = 0.40; I2:85.3)和脂联素水平(SMD = 0.08; 95%CI,-0.39,0.55; P = 0.74; I2:91.0)。与其他疾病(SMD 0.02; 95%CI,-0.29,0.33)和2型糖尿病(SMD- 0.17; 95%CI,-0.37,0.02)。总体而言,当前的荟萃分析表明,白藜芦醇的摄入量显着降低了体重,BMI,WC和脂肪量,并且显着增加了瘦肉量,但并未影响瘦素和脂联素的水平。与其他疾病(SMD 0.02; 95%CI,-0.29,0.33)和2型糖尿病(SMD- 0.17; 95%CI,-0.37,0.02)。总体而言,当前的荟萃分析表明,白藜芦醇的摄入量显着降低了体重,BMI,WC和脂肪量,并且显着增加了瘦肉量,但并未影响瘦素和脂联素的水平。与其他疾病(SMD 0.02; 95%CI,-0.29,0.33)和2型糖尿病(SMD- 0.17; 95%CI,-0.37,0.02)。总体而言,当前的荟萃分析表明,白藜芦醇的摄入量显着降低了体重,BMI,WC和脂肪量,并且显着增加了瘦肉量,但并未影响瘦素和脂联素的水平。
更新日期:2020-01-01
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