The tumor is becoming a critical threat to our lives in these years. Searching for antitumor substances from natural products is a great interest of scientists. Cudrania tricuspidata (C. tricuspidata) is a regional plant containing 158 flavonoids and 99 xanthones, and others ingredients with favorable bioactivity. This review comprehensively analyzes the antitumor compounds from C. tricuspidata against different tumors, and 78 flavonoids plus xanthones are considered as underlying antineoplastic. Importantly, the structure of preylation groups is the primary source of antitumor activity among 45 flavonoids plus xanthones, which could be a direction of structural modification for a better antitumor ability. Additionally, the fruits are also preferable sources of antitumor compounds compared to the roots and barks due to the abundant isoflavones and sustainability. However, many studies only focused on the cells viability inhibition of the compounds, the underlying molecular mechanisms, and the intracellular targets remain ambiguous. In conclusion, C. tricuspidata has a great potential for anti-tumor prevention or therapy, but more attention should be paid to deeper research in vitro and in vivo models.

中文翻译：

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来自Cu鱼的生物活性化合物：天然抗癌来源。

这些年来，肿瘤正成为对我们生命的严重威胁。从天然产物中寻找抗肿瘤物质是科学家的极大兴趣。dra草（C. tricuspidata）是一种区域性植物，含有158种黄酮类化合物和99种黄嘌呤，以及其他具有良好生物活性的成分。这篇综述全面分析了来自C. tricuspidata的抗肿瘤化合物对不同肿瘤的作用，其中78种类黄酮加黄嘌呤被认为是潜在的抗肿瘤药。重要的是，在45种类黄酮加黄嘌呤中，预酰化基团的结构是其抗肿瘤活性的主要来源，这可能是结构修饰的方向，以获得更好的抗肿瘤能力。此外，与水果的根和树皮相比，由于丰富的异黄酮和可持续性，水果也是抗肿瘤化合物的优选来源。然而，许多研究仅集中于化合物的细胞活力抑制，潜在的分子机制以及细胞内靶标仍然模棱两可。总之，C。tricuspidata在抗肿瘤的预防或治疗方面具有巨大的潜力，但应该更加关注更深入的体外和体内模型研究。