OBJECTIVE Mismatch negativity (MMN) has been continuously used to evaluate the functional integrity of central auditory processing. However, it still remains inconclusive whether patients with autism spectrum disorder (ASD) demonstrate reduced MMN responses in all deviant types. METHODS To reconcile the previous controversial findings, we performed a meta-analysis of peer-reviewed MMN articles concerning ASD. The potential moderators regarding different deviant types, diagnosis, and age on the effect sizes (Hedges' g) were also assessed. RESULTS Compared to the controls, ASD patients showed reduced MMN amplitudes (g = -0.37, p = 0.001) and prolonged latencies (g = -0.33, p = 0.041) in response to speech-sound deviants. Children/adolescents with ASD manifested reduced MMN amplitudes in response to tone-duration deviants (g = -0.46, p = 0.014). Furthermore, the results showed significantly shortened MMN latencies to tone-frequency deviants in patients with autism (g = 0.29, p = 0.038) and, in contrast, prolonged MMN latencies (g = -0.74, p = 0.001) in patients with Asperger syndrome. CONCLUSION MMN deficits are robust in ASD patients, suggesting an altered central ability in auditory discrimination. SIGNIFICANCE MMN alterations were displayed in different profiles with respect to frequency, duration and phoneme changes.

中文翻译：

---

自闭症谱系障碍中不同异常变化的不匹配负性：荟萃分析

目的 失配负性 (MMN) 一直被用于评估中央听觉处理的功能完整性。然而，自闭症谱系障碍 (ASD) 患者是否在所有异常类型中表现出降低的 MMN 反应仍然没有定论。方法 为了调和之前有争议的发现，我们对同行评审的 MMN 文章中关于 ASD 的文章进行了荟萃分析。还评估了关于不同异常类型、诊断和年龄对影响大小 (Hedges' g) 的潜在调节因素。结果 与对照组相比，ASD 患者响应语音-声音异常表现出降低的 MMN 振幅（g = -0.37，p = 0.001）和延长的延迟（g = -0.33，p = 0.041）。患有 ASD 的儿童/青少年表现出响应音调持续时间偏差的 MMN 振幅降低（g = -0.46，p = 0.014）。此外，结果显示自闭症患者的 MMN 潜伏期显着缩短（g = 0.29，p = 0.038），相反，阿斯伯格综合征患者的 MMN 潜伏期延长（g = -0.74，p = 0.001） . 结论 MMN 缺陷在 ASD 患者中很明显，表明听觉辨别的中枢能力发生了改变。显着性 MMN 改变在频率、持续时间和音素变化方面显示在不同的配置文件中。