Cycloartane triterpenoids from Pseudolarix amabilis and their antiviral activity,Phytochemistry

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Cycloartane triterpenoids from Pseudolarix amabilis and their antiviral activity
Phytochemistry ( IF 3.2 ) Pub Date : 2020-03-01 , DOI: 10.1016/j.phytochem.2019.112229
Xiao-Tong Zhao ₁ , Mei-Hua Yu ₁ , Shi-Yun Su ₁ , Xun-Long Shi ₁ , Chun Lei ₁ , Ai-Jun Hou ₁

Affiliation

Seven undescribed cycloartane triterpenoids, pseudolarnoids A-G, together with ten known ones, were isolated from the seeds of Pseudolarix amabilis (J. Nelson) Rehder. Their structures were elucidated on the basis of spectroscopic analysis, X-ray crystallography, and ECD data. Pseudolarnoids A-C are cycloartane triterpenoids with a unique 16S, 23R-spirolactone moiety. Pseudolarnoids F, G, and pseudolarolide C demonstrated potent antiviral effects on HSV-1 in vitro.

中文翻译：

来自 Pseudolarix amabilis 的 Cycloartane 三萜类化合物及其抗病毒活性

从 Pseudolarix amabilis (J. Nelson) Rehder 的种子中分离出 7 种未描述的环阿烷三萜类化合物、pseudolarnoids AG 以及 10 种已知的化合物。根据光谱分析、X 射线晶体学和 ECD 数据阐明了它们的结构。Pseudolarnoids AC 是具有独特的 16S、23R-螺内酯部分的环阿烷烃三萜类化合物。Pseudolarnoids F、G 和pseudolarolide C 在体外显示出对HSV-1 的有效抗病毒作用。

更新日期：2020-03-01

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