Centenarians are remarkable not only because of their prolonged life, but also because they compress morbidity until the very last moments of their lives, thus being proposed as a model of successful, extraordinary ageing. From the medical viewpoint, centenarians do not escape the physiological decline or the age-related diseases or syndromes (i.e. frailty), but the rate of such processes is slow enough to be counterbalanced by their increased intrinsic capacity to respond to minor stresses of daily life (i.e. resilience). These new concepts are reviewed in this paper. Allostatic stresses lead to a chronic low-grade inflammation that has led to the proposal of the "inflammaging" theory of ageing and frailty. The biology of centenarians, described in this review, provides us with clues for intervention to promote healthy ageing in the general population. One of the major reasons for this healthy ageing has to do with the genetic signature that is specific for centenarians and certainly different from octogenarians who do not enjoy the extraordinary qualities of centenarians.

中文翻译：

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百岁老人：成功衰老的韧性很好的例子。

百岁老人之所以出色，不仅是因为他们的寿命长，而且因为他们压缩了发病率直到生命的最后一刻，因此被推荐为成功，非凡的老龄化的典范。从医学的观点来看，百岁老人无法逃脱生理衰退或与年龄有关的疾病或综合症（即身体虚弱），但这种过程的速度很慢，足以抵消其对日常生活中较小压力的内在承受能力的提高。 （即弹性）。这些新概念在本文中进行了回顾。静应力导致慢性低度炎症，导致衰老和虚弱的“发炎”理论的提出。在这篇评论中描述了百岁老人的生物学，为我们提供了一些干预措施，以促进普通人群的健康老龄化。这种健康衰老的主要原因之一与百岁老人特有的遗传特征有关，而且肯定与不喜欢百岁老人特质的八十岁老人不同。