Facile Strategy to Synthesize Magnetic Upconversion Nanoscale Metal–Organic Framework Composites for Theranostics Application,ACS Applied Bio Materials

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Facile Strategy to Synthesize Magnetic Upconversion Nanoscale Metal–Organic Framework Composites for Theranostics Application
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-01-13 , DOI: 10.1021/acsabm.9b00949
Poulami Mukherjee ₁ , Amit Kumar ₁ , Keerti Bhamidipati ₂ , Nagaprasad Puvvada ₂ , Sumanta Kumar Sahu ₁

Affiliation

Recently, the design of a theranostics system has involved increasing attention in the area of biomedical applications. In many cases, the intricate synthesis process of upconversion nanoparticle-based composite materials limits the use of theranostics applications. To address this challenge, a nanocomposite has been successfully fabricated by the conjugation of magnetic NaGdF₄:Yb/Er nanoparticles as an imaging agent and MIL-53(Fe) as a drug carrier through a single step. Simultaneously, folic acid is encapsulated on the surface of the nanocomposite by conjugation chemistry to achieve the targeted drug delivery applications. The synthesized nanocomposite exhibits a sufficient amount of loading ability toward the model anticancer doxorubicin and possesses pH-responsive drug release. The functionalized nanocomposite not only possesses excellent colloidal stability and good magnetic and fluorescence property but also shows superior biocompatibility, strong tumor cell growth inhibitory effect, and cancer-enhanced cellular uptake. It is expected that the synthesized nanocomposite can also serve as a platform for both T₁ and T₂ MRI contrast agents.

中文翻译：

用于治疗诊断学应用的磁性上转换纳米级金属-有机框架复合材料的简便合成策略

最近，治疗诊断系统的设计在生物医学应用领域引起了越来越多的关注。在许多情况下，基于上转换纳米粒子的复合材料的复杂合成过程限制了治疗诊断学应用的使用。_{为了应对这一挑战，通过磁性 NaGdF 4}的共轭成功地制造了一种纳米复合材料。:Yb/Er 纳米粒子作为显像剂和 MIL-53(Fe) 作为药物载体通过一个步骤完成。同时，通过共轭化学将叶酸包裹在纳米复合材料的表面，实现靶向给药应用。合成的纳米复合材料对模型抗癌多柔比星表现出足够的负载能力，并具有pH响应性药物释放。功能化的纳米复合材料不仅具有优异的胶体稳定性和良好的磁性和荧光性能，而且表现出优异的生物相容性、强大的肿瘤细胞生长抑制作用和增强的细胞摄取能力。预计合成的纳米复合材料也可以作为 T ₁和 T ₂ MRI 造影剂的平台。

更新日期：2020-01-14

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