Currently, colorectal cancer (CRC) is one of the most common human malignant diseases in China and worldwide.^1,2 The development of distant metastasis is a leading cause of treatment failure and disease-related deaths. The liver is the most common site of metastasis in CRC patients, and approximately 50% of patients ultimately develop liver metastases during the course of disease progression.^3,4 Liver curative resection offers a phase of no evidence of disease (NED) and a chance for long-term survival for 50% of patients.^5,6 Unfortunately, more than 60% of patients develop recurrent disease during the subsequent follow-up after the initial liver resection.^7,8

中文翻译：

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结直肠肝寡转移灶中 TROP2 过表达与肝切除术后不良预后相关

目前，结直肠癌（CRC）是我国乃至世界范围内最常见的人类恶性肿瘤之一。^1,2远处转移的发展是治疗失败和疾病相关死亡的主要原因。肝脏是 CRC 患者最常见的转移部位，大约 50% 的患者最终在疾病进展过程中发生肝转移。^3,4肝根治性切除提供了一个无疾病证据 (NED) 的阶段，并为 50% 的患者提供了长期生存的机会。^5,6不幸的是，超过 60% 的患者在初次肝切除后的后续随访期间出现复发性疾病。^7,8