BACKGROUND The influence of socioeconomic deprivation on the cardiovascular health of patients with psychosis-spectrum disorders (PSD) has not been investigated despite the growing recognition of social factors as determinants of health, and the disproportionate rates of cardiovascular mortality observed in PSD. Discordant results have been documented when studying dyslipidemia -a core cardiovascular risk factor- in first-episode psychosis (FEP), before chronic exposure to antipsychotic medications. The objective of the present study is to determine the extent to which socioeconomic deprivation affects blood lipids in patients with FEP, and examine its implications for cardiovascular risk in PSD. METHODS Linear regression models, controlling for age, sex, exposure to pharmacotherapy, and physical anergia, were used to test the association between area-based measures of material and social deprivation and blood lipid levels in a sample of FEP patients (n = 208). RESULTS Social, but not material deprivation, was associated with lower levels of total and HDL cholesterol. This effect was statistically significant in patients with affective psychoses, but not in schizophrenia-spectrum disorders. CONCLUSIONS Contrary to other reports from the literature, the relationship between socioeconomic disadvantage and blood lipid levels was contingent on the social rather than the material aspects of deprivation. Furthermore, this association also depended on the main diagnostic category of psychosis, suggesting a complex interaction between the environment, psychopathology, and physical health. Future studies exploring health issues in psychosis might benefit from taking these associations into consideration. A better understanding of the biology of blood lipids in this context is necessary.

中文翻译：

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最小抗精神病药物暴露的首发精神病患者的社会经济剥夺和血脂：对心血管风险的影响

背景 社会经济剥夺对精神病谱系障碍 (PSD) 患者心血管健康的影响尚未得到研究，尽管社会因素是健康的决定因素，并且在 PSD 中观察到的心血管死亡率不成比例。在长期接触抗精神病药物之前，研究首发精神病 (FEP) 中的血脂异常（一种核心心血管危险因素）时，结果不一致。本研究的目的是确定社会经济剥夺对 FEP 患者血脂的影响程度，并检查其对 PSD 心血管风险的影响。方法 线性回归模型，控制年龄、性别、药物治疗暴露和身体失能症，用于测试 FEP 患者样本（n = 208）中基于区域的物质和社会剥夺测量与血脂水平之间的关联。结果 社会而非物质剥夺与较低水平的总胆固醇和高密度脂蛋白胆固醇有关。这种影响在情感性精神病患者中具有统计学意义，但在精神分裂症谱系障碍中没有统计学意义。结论 与文献中的其他报告相反，社会经济劣势与血脂水平之间的关系取决于社会而非物质方面的剥夺。此外，这种关联还取决于精神病的主要诊断类别，表明环境、精神病理学和身体健康之间存在复杂的相互作用。未来探索精神病健康问题的研究可能会受益于考虑这些关联。在这种情况下，更好地了解血脂的生物学是必要的。