Abstract In the present study, the sulfobetaine-based copolymer bearing a dopamine functionality showed gel formation adjusted by the application of metal salts for gelation and various values of pH. Normally, the liquid-like solution of the sulfobetaine-based copolymer and metal cross-linkers is transformed to a gel-like state upon increasing the pH values in the presence of Fe 3+ and Ti 3+ . Metal-induced coordination is reversible by means of the application of EDTA as a chelating agent. In the case of Ag + ions, the gel is formed through a redox process accompanied with the oxidative coupling of the dopamine moieties and Ag 0 particle formation. Mussel-mimicking and metal-dependent viscoelastic properties were observed for Fe 3+ , Ti 3+ , and Ag + cross-linking agents, with additionally enhanced self-healing behavior in comparison with the covalently cross-linked IO 4 − analogues. Antibacterial properties can be achieved both in solution and on the surface using the proper concentration of Ag + ions used for gelation; thus, a tunable amount of the Ag 0 particles are formed in the hydrogel. The cytotoxicity was elucidated by the both MTT assay on the NIH/3T3 fibroblast cell line and direct contact method using human dermal fibroblast cell (F121) and shows the non-toxic character of the synthesized copolymer.

中文翻译：

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具有金属可调凝胶化、自愈和抗菌能力的仿贻贝磺基甜菜碱共聚物

摘要 在本研究中，带有多巴胺官能团的磺基甜菜碱基共聚物显示出凝胶形成可通过应用金属盐进行凝胶化和各种 pH 值进行调节。通常，在Fe 3+ 和Ti 3+ 存在下提高pH值时，磺基甜菜碱基共聚物和金属交联剂的液体状溶液转变为凝胶状状态。通过使用 EDTA 作为螯合剂，金属诱导的配位是可逆的。在 Ag + 离子的情况下，凝胶是通过氧化还原过程形成的，同时伴随着多巴胺部分的氧化偶联和 Ag 0 颗粒的形成。对于 Fe 3+ 、Ti 3+ 和 Ag + 交联剂，观察到模仿贻贝和金属依赖性粘弹性，与共价交联的IO 4 - 类似物相比，具有额外增强的自愈行为。使用适当浓度的用于凝胶化的 Ag + 离子，可以在溶液中和表面上实现抗菌性能；因此，在水凝胶中形成了可调节量的Ag 0 颗粒。通过对 NIH/3T3 成纤维细胞系的 MTT 测定和使用人真皮成纤维细胞 (F121) 的直接接触方法阐明了细胞毒性，并显示了合成共聚物的无毒特性。