Abstract In this study, novel smart drug release films were prepared by blending chitosan with polyethylene glycol methyl ether (PEGME), also named as methoxy polyethylene glycol (mPEG), for controlled drug release applications. The polymeric films were characterized by Fourier transform infra-red for functional groups analysis, scanning electron microscopy for morphology and X-ray photoelectron spectroscopy for chemical and surface analysis followed by mechanical and thermal analysis. The mechanical properties showed that with the addition of PEGME (40%), the tensile strength and elongation break were increased up to 34.14 MPa and 26.40%, respectively as compared to the controlled sample (without PEGME). The developed biodegradable films were tested for Metformin hydrogen chloride release ability at a particular rate in phosphate buffer saline solution at pH 7.4. The results showed that chitosan/PEGME blends could be employed for controlled drug release and other biomedical applications.

中文翻译：

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基于壳聚糖/聚（乙二醇）甲基醚混合物的可生物降解薄膜中氯化二甲双胍的受控药物释放行为

摘要 在本研究中，通过将壳聚糖与聚乙二醇甲基醚（PEGME）（也称为甲氧基聚乙二醇（mPEG））共混制备了新型智能释药薄膜，用于药物控释应用。聚合物薄膜的特征是通过傅里叶变换红外进行官能团分析、扫描电子显微镜进行形态学和 X 射线光电子能谱进行化学和表面分析，然后进行机械和热分析。力学性能表明，与对照样品（不含 PEGME）相比，加入 PEGME（40%）后，拉伸强度和断裂伸长率分别增加了 34.14 MPa 和 26.40%。开发的可生物降解薄膜在 pH 7.4 的磷酸盐缓冲盐水溶液中以特定速率测试二甲双胍氯化氢释放能力。结果表明，壳聚糖/PEGME 混合物可用于控制药物释放和其他生物医学应用。