In this work, thiophene derivatives were synthesized in good yields via multicomponent reaction of isoquinoline, alkyl bromides, activated acetylenic compounds, isothiocyanates, and catalytic amounts of ZnO nanorods (NRs) at room temperature under solvent‐free conditions. This procedure for the synthesis of thiophene derivatives is green, easy, and simple with excellent yield. In addition, DPPH radical scavenging and ferric reduction power experiment has been studied for the evaluation of the antioxidant activity of some prepared thiophenes, for example, 5b, 5d, 5e, and 5f. As outcome, the compound 5d exhibited a noteworthy radical trapping activity and excellent reducing ability than synthetic antioxidants such as butylated hydroxytoluene (BHT) and 2‐tertbutylhydroquinone (TBHQ). Moreover, the antimicrobial activity of some synthesized thiophenes was confirmed by employing the disk diffusion test on Gram‐positive and Gram‐negative bacteria. The obtained results of disk diffusion test showed that compounds 5b, 5d, 5e, and 5f prevented bacterial growth.

中文翻译：

---

ZnO纳米棒作为绿色合成噻吩衍生物的有效催化剂：抗氧化剂和抗菌活性的研究

在这项工作中，通过在无溶剂条件下于室温下进行的异喹啉，烷基溴化物，活化的炔属化合物，异硫氰酸酯和催化量的ZnO纳米棒（NRs）的多组分反应，以高收率合成了噻吩衍生物。该合成噻吩衍生物的方法绿色环保，简单易行，收率高。另外，还研究了DPPH自由基清除和三价铁还原能力的实验，以评价一些制备的噻吩的抗氧化活性，例如5b，5d，5e和5f。结果，化合物5d与丁基化羟基甲苯（BHT）和2-叔丁基对苯二酚（TBHQ）等合成抗氧化剂相比，具有显着的自由基捕获活性和出色的还原能力。此外，通过对革兰氏阳性和革兰氏阴性细菌进行圆盘扩散试验，证实了一些合成的噻吩的抗菌活性。圆盘扩散试验的结果表明，化合物5b，5d，5e和5f阻止了细菌的生长。