Xanthophyll β-Cryptoxanthin Inhibits Highly Refined Carbohydrate Diet-Promoted Hepatocellular Carcinoma Progression in Mice.,Molecular Nutrition & Food Research

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Xanthophyll β-Cryptoxanthin Inhibits Highly Refined Carbohydrate Diet-Promoted Hepatocellular Carcinoma Progression in Mice.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-01-09 , DOI: 10.1002/mnfr.201900949
Ji Ye Lim _{1,

2} , Chun Liu ₁ , Kang-Quan Hu ₁ , Donald E Smith ₃ , Dayong Wu _{2,

4} , Stefania Lamon-Fava _{2,

5} , Lynne M Ausman _{1,

2} , Xiang-Dong Wang _{1,

2}

Affiliation

β‐Cryptoxanthin (BCX) can be cleaved by both β‐carotene 15,15′‐oxygenase (BCO1) and β‐carotene 9′,10′‐oxygenase (BCO2), generating biological active vitamin A and apocarotenoids. We examined whether BCX feeding could inhibit diethylnitrosamine (DEN)‐initiated, highly refined carbohydrate diet (HRCD)‐promoted hepatocellular carcinoma (HCC) development, dependent or independent of BCO1/BCO2 activity.

中文翻译：

叶黄素β-隐黄质抑制高精饮食饮食促进的肝细胞癌进展。

β-隐黄质（BCX）可以被β-胡萝卜素15,15'-加氧酶（BCO1）和β-胡萝卜素9'，10'-加氧酶（BCO2）裂解，从而产生生物活性维生素A和类胡萝卜素。我们检查了BCX喂养是否可以抑制依赖或不依赖BCO1 / BCO2活性的二乙基亚硝胺（DEN）引发的高度精制的碳水化合物饮食（HRCD）促进的肝细胞癌（HCC）的发展。

更新日期：2020-01-09

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