Daphne giraldii Nitsche., a member of the genus Daphne (Thymelaeaceae), is a deciduous shrub with mild toxicity. Its rhizome bark, generally called 'Zushima' in Chinese, has many medicinal folkloric uses and good therapeutic effects. Previous studies investigating the chemical constituents and pharmacological activities of D. giraldii have focused on several major classes of compounds, such as coumarins, lignans and flavonoids, especially the interesting enantiomeric flavans. Extracts and pure compounds of D. giraldii were found to possess anti-inflammatory, anti-nociceptive, cytotoxicity, antimalarial, immunomodulating, sedative and hypnotic effects. They have also been reported to influence the cardiovascular functions and blood activities. This comprehensive review will describe the advances in the phytochemistry, pharmacology, medicinal uses and clinical applications of D. giraldii and its formulations covering the literature published from 1970 to 2018. Almost half of the reviewed studies were originally published in non-English languages (mainly in Chinese). Collectively, the aim of this article is to open new avenues for further in-depth pharmacological studies on D. giraldii.

中文翻译：

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Daphne giraldii Nitsche（百里香科）：植物化学、药理学和药用

Daphne giraldii Nitsche. 是 Daphne (Thymelaeaceae) 属的成员，是一种具有轻度毒性的落叶灌木。其根茎皮，俗称“祖岛”，有多种药用民俗用途和良好的食疗作用。以前研究 D. giraldii 的化学成分和药理活性的研究集中在几个主要类别的化合物上，例如香豆素、木脂素和类黄酮，尤其是有趣的对映体黄烷。发现 D. giraldii 的提取物和纯化合物具有抗炎、抗伤害性、细胞毒性、抗疟、免疫调节、镇静和催眠作用。据报道，它们还会影响心血管功能和血液活动。这篇综合评论将描述植物化学、药理学、D. giraldii 的药用和临床应用及其制剂涵盖了 1970 年至 2018 年发表的文献。几乎一半的审查研究最初以非英语语言（主要是中文）发表。总的来说，本文的目的是为 D. giraldii 的进一步深入药理研究开辟新的途径。