A growing body of evidence suggests that long non-coding RNAs (lncRNAs), a novel class of non-coding endogenous single-stranded RNA, play a key role in multiple physiological and pathological processes through transcriptional interference, post-transcriptional regulation, and epigenetic modification. Furthermore, many studies have shown that lncRNAs-as oncogenes or tumour suppressors-play an important role in the occurrence and development of human cancers. Small nucleolar RNA host gene 16 (SNHG16) was initially identified as an oncogenic lncRNA in neuroblastoma, and has since been identified as a carcinogenic regulator of various malignant tumours. Overexpression of SNHG16 is associated with clinical and pathological characteristics of cancer patients, and regulates cell proliferation, apoptosis, invasion and metastasis through a variety of potential mechanisms. Therefore, SNHG16 may be a promising biomarker and therapeutic target for cancers. In this review, we summarize the biological function, related mechanisms and potential clinical significance of SNHG16 in multiple human cancers.

中文翻译：

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SNHG16在人类癌症中的作用。

越来越多的证据表明，长的非编码RNA（lncRNA）是一类新型的非编码内源性单链RNA，通过转录干扰，转录后调控和表观遗传学在多种生理和病理过程中起着关键作用。修改。此外，许多研究表明，lncRNAs（作为癌基因或抑癌基因）在人类癌症的发生和发展中起着重要作用。小核仁RNA宿主基因16（SNHG16）最初被鉴定为神经母细胞瘤中的致癌lncRNA，此后被鉴定为各种恶性肿瘤的致癌调节剂。SNHG16的过度表达与癌症患者的临床和病理特征有关，并调节细胞增殖，凋亡，通过多种潜在机制进行侵袭和转移。因此，SNHG16可能是有希望的癌症生物标志物和治疗靶标。在这篇综述中，我们总结了SNHG16在多种人类癌症中的生物学功能，相关机制和潜在的临床意义。