We read with great interest the paper of Ishikawa et al ,1 which addressed the link between smoking and the levels of anti-citrullinated protein antibodies(ACPA) and rheumatoid factor (RF) in a total of 6239 Japanese rheumatoid arthritis (RA) patients. We particularly appreciate the detailed smoking history collected that allowed a very detailed analysis. The authors collected information about the number of cigarette packs smoked per day, the years smoking and the time of smoke cessation when it was present. They also distinguished the ever smoker patients in three categories: smokers at disease onset, ex-smokers before onset and smokers after onset, which looks like a very …

中文翻译：

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Ishikawa 等人关于“共享表位定义了吸烟与抗瓜氨酸蛋白抗体和类风湿因子水平的不同关联”的对应关系

我们非常感兴趣地阅读了 Ishikawa 等人的论文 1，该论文探讨了 6239 名日本类风湿性关节炎 (RA) 患者的吸烟与抗瓜氨酸蛋白抗体 (ACPA) 和类风湿因子 (RF) 水平之间的联系。我们特别感谢收集到的详细吸烟史，以便进行非常详细的分析。作者收集了有关每天吸烟数量、吸烟年限和戒烟时间的信息。他们还将曾经吸烟的患者分为三类：发病时的吸烟者、发病前的戒烟者和发病后的吸烟者，这看起来像一个非常……