Construction and application of targeted drug delivery system based on hyaluronic acid and heparin functionalised carbon dots.,Colloids and Surfaces B: Biointerfaces

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Construction and application of targeted drug delivery system based on hyaluronic acid and heparin functionalised carbon dots.
Colloids and Surfaces B: Biointerfaces ( IF 5.4 ) Pub Date : 2019-12-31 , DOI: 10.1016/j.colsurfb.2019.110768
Qianqian Duan ₁ , Lan Ma ₁ , Boye Zhang ₁ , Yixia Zhang ₁ , Xiaoning Li ₂ , Tao Wang ₃ , Wendong Zhang ₁ , Yi Li ₄ , Shengbo Sang ₁

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Thrombosis is a main complication of cancer. It can increase the mortality of cancer patients. Therefore, the anticoagulant heparin (Hep) as an adjuvant therapy was introduced to the drug delivery system based on doxorubicin hydrochloride (DOX)-carbon dots (CDs)-Hyaluronic acid (HA), which obviously enhanced the blood compatibility of the system. Drug release process of the CDs-HA-Hep/DOX system was dual-responsive by HA and pH value. Results of in vitro MTT and scratch tests demonstrated that the drug delivery system could targetedly inhibit growth and migration of cancerous cells. In addition, the system allows visual tracking of the drug based on fluorescence of CDs.

中文翻译：

基于透明质酸和肝素功能化碳点的靶向药物递送系统的构建和应用。

血栓形成是癌症的主要并发症。它可以增加癌症患者的死亡率。因此，将抗凝性肝素（Hep）作为辅助疗法引入了基于盐酸阿霉素（DOX）-碳点（CDs）-透明质酸（HA）的药物递送系统，明显增强了系统的血液相容性。CDs-HA-Hep / DOX系统的药物释放过程受HA和pH值双重响应。体外MTT和刮擦试验的结果表明，药物输送系统可以针对性地抑制癌细胞的生长和迁移。此外，该系统还可以基于CD的荧光对药物进行视觉跟踪。

更新日期：2019-12-31

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