This study aimed to quantify the relationship between postpartum depression and anxiety, oxytocin, and breastfeeding. We conducted a longitudinal prospective study of mother-infant dyads from the third trimester of pregnancy to 12 months postpartum. A sample of 222 women were recruited to complete the Beck Depression Inventory II and Spielberger State-Trait Anxiety Inventory-state subscale, participate in observed infant feeding sessions at 2 and 6 months postpartum, and provide venous blood samples during feeding. Maternal venous oxytocin levels in EDTA-treated plasma and saliva were determined by enzyme immunoassay with extraction and a composite measure of area under the curve (AUC) was used to define oxytocin across a breastfeeding session. Linear regression was used to estimate associations between postpartum depression and anxiety as predictors and oxytocin AUC during breastfeeding as the outcome at both 2 and 6 months postpartum. Mixed models accounting for correlations between repeated oxytocin measures were used to quantify the association between current depression and/or anxiety symptoms and oxytocin profiles during breastfeeding. We found no significant differences in oxytocin AUC across a feed between depressed or anxious women and asymptomatic women at either 2 or 6 months postpartum. Repeated measures analyses demonstrated no differences in oxytocin trajectories during breastfeeding by symptom group but possible differences by antidepressant use. Our study suggests that external factors may influence the relationship between oxytocin, maternal mood symptoms, and infant feeding.

中文翻译：

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母乳喂养期间的催产素和母亲情绪症状

本研究旨在量化产后抑郁与焦虑、催产素和母乳喂养之间的关系。我们对从妊娠晚期到产后 12 个月的母婴二人进行了一项纵向前瞻性研究。招募了 222 名女性样本来完成贝克抑郁量表 II 和斯皮尔伯格状态-特质焦虑量表-状态分量表，参与观察产后 2 个月和 6 个月的婴儿喂养会议，并在喂养期间提供静脉血样本。经 EDTA 处理的血浆和唾液中的母体静脉催产素水平通过酶免疫分析法和提取法测定，曲线下面积 (AUC) 的综合测量值用于定义整个母乳喂养期间的催产素。线性回归用于估计产后抑郁和焦虑作为预测因素和母乳喂养期间催产素 AUC 作为产后 2 个月和 6 个月结果之间的关联。考虑到重复催产素测量之间相关性的混合模型被用于量化当前抑郁和/或焦虑症状与母乳喂养期间催产素谱之间的关联。我们发现，在产后 2 个月或 6 个月，抑郁或焦虑女性与无症状女性之间的催产素 AUC 没有显着差异。重复测量分析表明，母乳喂养期间不同症状组的催产素轨迹没有差异，但可能因使用抗抑郁药而有所不同。我们的研究表明，外部因素可能会影响催产素、母亲情绪症状、