Neurogenesis in the human postnatal brain occurs in two regions, the subventricular zone of the later ventricle and the dentate gyrus of the hippocampus. While it is well accepted that SVZ and hippocampal neurogenesis are active during juvenile stages in human, their contribution during adulthood and ageing as well as pathological states is recently animating the neural stem cell research field. In this review we will discuss recent evidence about the organization of SVZ and hippocampal neurogenic niches, and will report on how human adult neurogenesis may contribute to disease and appears to respond to neurodegeneration. In light of these novel findings, we will discuss how we can target human adult neurogenesis in order to influence brain disease trajectories.

中文翻译：

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弄清人类神经发生机制，以了解和应对脑部疾病。

人类产后大脑的神经发生发生在两个区域，即后脑室的脑室下区和海马的齿状回。尽管人们普遍认为SVZ和海马神经发生在人类的幼年阶段是活跃的，但它们在成年和衰老以及病理状态中的作用最近正在推动神经干细胞研究领域的发展。在这篇综述中，我们将讨论有关SVZ和海马神经源性壁ches组织的最新证据，并将报告人类成年神经发生如何可能导致疾病并似乎对神经退行性反应。根据这些新颖的发现，我们将讨论如何针对成年人的神经发生以影响脑部疾病的发展轨迹。