Matsushita et al. describe a model of acute kidney injury to chronic kidney disease progression in mice surviving cardiac arrest: mice develop severe acute kidney injury that initially recovers but is followed by the onset of impaired renal function on longer-term follow-up. These findings suggest that distinct cardiorenal toxicities and/or injury dynamics are operative in this cardiac arrest model that do not occur in traditional models of acute kidney injury, providing new opportunities for therapeutic and biomarker discovery for an important clinical problem.

中文翻译：

---

人类疾病建模：心脏骤停后急性肾损伤到慢性肾病进展的小鼠模型。


松下等人。描述了心脏骤停幸存小鼠的急性肾损伤到慢性肾病进展的模型：小鼠出现严重的急性肾损伤，最初恢复，但在长期随访中出现肾功能受损。这些发现表明，在这种心脏骤停模型中，不同的心肾毒性和/或损伤动态起作用，而这在传统的急性肾损伤模型中不会发生，这为重要临床问题的治疗和生物标志物发现提供了新的机会。