Characterization of chitosan-lysine surfactant bioactive coating on silicone substrate.,Carbohydrate Polymers

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Characterization of chitosan-lysine surfactant bioactive coating on silicone substrate.
Carbohydrate Polymers ( IF 10.7 ) Pub Date : 2019-12-31 , DOI: 10.1016/j.carbpol.2019.115817
Urban Ajdnik ₁ , Matjaž Finšgar ₂ , Lidija Fras Zemljič ₁

Affiliation

Chitosan (Chi) and anionic surfactant derived from lysine (77KS) were used to prepare a novel bioactive coating and as a drug delivery system for amoxicillin (AMOX) on a model polydimethylsiloxane (PDMS) surface. The bioactive coating was formulated as polyelectrolyte-surfactant complex (PESC). Aggregation behaviour between the cationic Chi and oppositely charged 77KS in bulk was analysed using turbidity and ζ-potential measurement. Furthermore, the adsorption and stability of the formulations were evaluated using quartz crystal microbalance with dissipation (QCM-D). The effect of the ionic strength and of the ultraviolet/ozone (UVO) activation of the PDMS films on the adsorption behaviour of the PESC complex was also examined. QCM-D monitoring showed stable adsorption of bare and AMOX-loaded complex on non-activated PDMS films, while the coating on UVO-activated PDMS samples desorbed after the rinsing step. Finally, X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry confirmed successful and homogenously distributed compounds.

中文翻译：

聚硅氧烷表面上的壳聚糖-赖氨酸表面活性剂生物活性涂层的表征。

壳聚糖（Chi）和衍生自赖氨酸的阴离子表面活性剂（77KS）用于制备新型生物活性涂层，并用作模型聚二甲基硅氧烷（PDMS）表面上阿莫西林（AMOX）的药物递送系统。将生物活性涂层配制为聚电解质-表面活性剂复合物（PESC）。使用浊度和ζ电位测量分析了阳离子Chi和带相反电荷的77KS之间的聚集行为。此外，使用具有耗散的石英晶体微量天平（QCM-D）评价了制剂的吸附和稳定性。还检查了离子强度和PDMS膜的紫外线/臭氧（UVO）活化对PESC配合物吸附行为的影响。QCM-D监测显示裸露和AMOX负载的复合物在未活化的PDMS膜上的稳定吸附，漂洗步骤后，UVO活化的PDMS样品上的涂层解吸。最后，X射线光电子能谱和飞行时间二次离子质谱法证实了成功且均质分布的化合物。

更新日期：2019-12-31

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