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Thai glutinous rice starch modified by ball milling and its application as a mucoadhesive polymer.
Carbohydrate Polymers ( IF 10.7 ) Pub Date : 2019-12-31 , DOI: 10.1016/j.carbpol.2019.115812 May Thu Soe 1 , Padungkwan Chitropas 2 , Thaned Pongjanyakul 2 , Ekapol Limpongsa 3 , Napaphak Jaipakdee 4
Carbohydrate Polymers ( IF 10.7 ) Pub Date : 2019-12-31 , DOI: 10.1016/j.carbpol.2019.115812 May Thu Soe 1 , Padungkwan Chitropas 2 , Thaned Pongjanyakul 2 , Ekapol Limpongsa 3 , Napaphak Jaipakdee 4
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This study aimed to investigate physicochemical properties and potential application as a mucoadhesive polymer of Thai glutinous rice starch modified by planetary ball milling. XRD and ATR-FTIR results indicated a reduction in crystallinity of starch after ball milling. Different ball milling times, ranging from 5 to 45 min, resulted in modified glutinous rice starch (MGRS) with different levels of crystallinity loss, and therefore varying degrees of cold water solubility, swelling capacity, and gelatinized dispersion viscosity. Investigation of mucoadhesive properties using Texture Analyzer with porcine mucosa demonstrated that MGRS tablets exhibited greater mucoadhesive abilities compared to hydroxypropyl methylcellulose tablets, but weaker than those of sodium carboxymethylcellulose tablets. Tablets made of 15-min-milled MGRS had comparable tableting, swelling and mucoadhesiveness, but lower erosion compared to 45-min-milled MGRS. Conclusively, ball milling treatment could successfully induce the mucoadhesive properties of Thai glutinous rice starch and expand its application as mucoadhesive polymer.
中文翻译：
球磨改性的泰国糯米淀粉及其作为粘膜粘附聚合物的应用。
这项研究旨在研究物理化学性质和作为行星球磨改性的泰国糯米淀粉的粘膜粘附聚合物的潜在应用。XRD和ATR-FTIR结果表明球磨后淀粉的结晶度降低。球磨时间从5到45分钟不等，导致改性糯米淀粉（MGRS）的结晶度损失程度不同，因此冷水溶解度，溶胀能力和糊化分散体粘度的程度也不同。使用质地分析仪和猪粘膜对粘膜粘附特性的研究表明，与羟丙基甲基纤维素片相比，MGRS片剂显示出更大的粘膜粘附能力，但比羧甲基纤维素钠片弱。由研磨时间为15分钟的MGRS制成的片剂具有相当的压片，溶胀和粘膜粘附性，但与研磨时间为45分钟的MGRS相比，其侵蚀较少。最后，球磨处理可以成功地诱导泰国糯米淀粉的粘膜粘附特性，并扩展其作为粘膜粘附聚合物的应用。
更新日期：2019-12-31
中文翻译：
球磨改性的泰国糯米淀粉及其作为粘膜粘附聚合物的应用。
这项研究旨在研究物理化学性质和作为行星球磨改性的泰国糯米淀粉的粘膜粘附聚合物的潜在应用。XRD和ATR-FTIR结果表明球磨后淀粉的结晶度降低。球磨时间从5到45分钟不等，导致改性糯米淀粉（MGRS）的结晶度损失程度不同，因此冷水溶解度，溶胀能力和糊化分散体粘度的程度也不同。使用质地分析仪和猪粘膜对粘膜粘附特性的研究表明，与羟丙基甲基纤维素片相比，MGRS片剂显示出更大的粘膜粘附能力，但比羧甲基纤维素钠片弱。由研磨时间为15分钟的MGRS制成的片剂具有相当的压片，溶胀和粘膜粘附性，但与研磨时间为45分钟的MGRS相比，其侵蚀较少。最后，球磨处理可以成功地诱导泰国糯米淀粉的粘膜粘附特性，并扩展其作为粘膜粘附聚合物的应用。
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