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Surface-Directed Selection of Dynamic Constitutional Frameworks as an Optimized Microenvironment for Controlled Enzyme Activation
ACS Catalysis ( IF 11.3 ) Pub Date : 2020-01-06 , DOI: 10.1021/acscatal.9b04938 Yan Zhang 1 , Mihail Barboiu 2 , Olof Ramström 3, 4 , Jinghua Chen 1
ACS Catalysis ( IF 11.3 ) Pub Date : 2020-01-06 , DOI: 10.1021/acscatal.9b04938 Yan Zhang 1 , Mihail Barboiu 2 , Olof Ramström 3, 4 , Jinghua Chen 1
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Dynamic constitutional frameworks composed of cross-linked networks of imine-exchanging components have been generated and applied to the establishment of optimal microenvironments for carbonic anhydrase (CA) in aqueous solution. In response to the dynamic recomposition process, the enzyme showed distinct differential preferences for interchanging and incorporation of the amine functionalities, which were furthermore in good correlation with their inverse activation effects of CA. The results demonstrated surface-directed selection of the enzyme environment, where amines with lower enzyme-directed incorporation ratio possess higher activation effects, leading to a strategy of self-optimization of the enzyme microenvironment for better catalytic performances.
中文翻译：
动态构造框架的表面定向选择作为控制酶激活的最佳微环境
由亚胺交换组分的交联网络组成的动态结构框架已生成，可用于建立水溶液中碳酸酐酶（CA）的最佳微环境。响应于动态重组过程，该酶在胺官能团的交换和掺入方面表现出明显的差异偏好，此外，其与CA的逆活化作用具有良好的相关性。结果证明了酶环境的表面定向选择，其中具有较低的酶定向掺入比的胺具有较高的活化作用，从而导致了酶微环境的自优化策略以具有更好的催化性能。
更新日期：2020-01-07
中文翻译：
动态构造框架的表面定向选择作为控制酶激活的最佳微环境
由亚胺交换组分的交联网络组成的动态结构框架已生成，可用于建立水溶液中碳酸酐酶（CA）的最佳微环境。响应于动态重组过程，该酶在胺官能团的交换和掺入方面表现出明显的差异偏好，此外，其与CA的逆活化作用具有良好的相关性。结果证明了酶环境的表面定向选择，其中具有较低的酶定向掺入比的胺具有较高的活化作用，从而导致了酶微环境的自优化策略以具有更好的催化性能。
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