Marburg virus (MARV) is a highly pathogenic virus associated with severe disease and mortality rates as high as 90%. Outbreaks of MARV are sporadic, deadly, and often characterized by a lack of resources and facilities to diagnose and treat patients. There are currently no approved vaccines or treatments, and the chaotic and infrequent nature of outbreaks, among other factors, makes testing new countermeasures during outbreaks ethically and logistically challenging. Without field efficacy studies, researchers must rely on animal models of MARV infection to assess the efficacy of vaccines and treatments, with the limitations being the accuracy of the animal model in recapitulating human pathogenesis. This review will compare various animal models to the available descriptions of human pathogenesis and aims to evaluate their effectiveness in modeling important aspects of Marburg virus disease.

中文翻译：

---

马尔堡病毒的发病机理-人类和动物模型的异同。

马尔堡病毒（MARV）是一种高致病性病毒，伴有严重的疾病，死亡率高达90％。MARV的暴发是零星的，致命的，并且通常以缺乏诊断和治疗患者的资源和设施为特征。目前尚无批准的疫苗或治疗方法，而且暴发的混乱和偶发性以及其他因素使得在暴发期间测试新的对策在道德和后勤方面都具有挑战性。没有现场功效研究，研究人员必须依靠MARV感染的动物模型来评估疫苗和治疗的功效，其局限性在于动物模型在概括人类发病机理方面的准确性。