Background The sequelae of sepsis were once thought to be independent of sepsis itself and assumed to be either comorbid to sick patients or complications of critical illness. Recent studies have reported consistent patterns of functional disabilities in sepsis survivors that can last from months to years after symptoms of active sepsis had resolved. Body Post-sepsis syndrome is an emerging pathological entity that has garnered significant interest amongst clinicians and researchers over the last two decades. It is marked by a significantly increased risk of death and a poor health-related quality of life associated with a constellation of long-term effects that persist following the patient’s bout with sepsis. These include neurocognitive impairment, functional disability, psychological deficits, and worsening medical conditions. Conclusion This “post-sepsis syndrome” has been the subject of active preclinical and clinical research providing new mechanistic insights and approaches linked to survivor well-being. Here we review important aspects of these research efforts and goals of care for patients who survive sepsis.

中文翻译：

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脓毒症后综合症——一种折磨脓毒症幸存者的不断发展的实体


背景 脓毒症的后遗症曾被认为与脓毒症本身无关，并被认为是病人的共病或危重疾病的并发症。最近的研究报告称，脓毒症幸存者存在一致的功能障碍模式，这种模式在活动性脓毒症症状消失后可持续数月至数年。身体脓毒症后综合征是一种新兴的病理实体，在过去二十年中引起了临床医生和研究人员的极大兴趣。其特点是死亡风险显着增加，健康相关的生活质量下降，并与患者患败血症后持续存在的一系列长期影响相关。这些包括神经认知障碍、功能障碍、心理缺陷和恶化的医疗状况。结论 这种“脓毒症后综合征”一直是积极的临床前和临床研究的主题，提供与幸存者福祉相关的新机制见解和方法。在这里，我们回顾这些研究工作的重要方面以及脓毒症幸存者的护理目标。