BACKGROUND In 2015, Nigeria's estimated 317,700 stillbirths accounted for 12.2% of the 2.6 million estimated global stillbirths. This suggests that Nigeria still makes substantial contribution to the global burden of stillbirths. This study was conducted to determine the prevalence and identify the causes and factors associated with stillbirth in eight referral hospitals in Nigeria. METHODS This was a cross-sectional study of all deliveries over a period of 6 months in six general hospitals (4 in the south and 2 in the north), and two teaching hospitals (both in the north) in Nigeria. The study population was women delivering in the hospitals during the study period. A pre-tested study protocol was used to obtain clinical data on pregnancies, live births and stillbirths in the hospitals over a 6 months period. Data were analyzed centrally using univariate, bivariate and multivariate logistic regression analyses. The main outcome measure was stillbirth rate in the hospitals (individually and overall). RESULTS There were 4416 single births and 175 stillbirths, and a mean stillbirth rate of 39.6 per 1000 births (range: 12.7 to 67.3/1000 births) in the hospitals. Antepartum (macerated) constituted 22.3% of the stillbirths; 47.4% were intrapartum (fresh stillbirths); while 30.3% was unclassified. Acute hypoxia accounted for 32.6% of the stillbirths. Other causes were maternal hypertensive disease (6.9%), and intrapartum unexplained (5.7%) among others. After adjusting for confounding variables, significant predictors of stillbirth were referral status, parity, past experience of stillbirth, birth weight, gestational age at delivery and mode of delivery. CONCLUSION We conclude that the rate of stillbirth is high in Nigeria's referral hospitals largely because of patients' related factors and the high rates of pregnancy complications. Efforts to address these factors through improved patients' education and emergency obstetric care would reduce the rate of stillbirth in the country. TRIAL REGISTRATION Trial Registration Number NCTR91540209. Nigeria Clinical Trials Registry. http://www.nctr.nhrec.net/ Registered April 14th 2016.

中文翻译：

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尼日利亚转诊医院死胎的发生率和决定因素：一项多中心研究。

背景技术2015年，尼日利亚估计有317,700个死产，占全球估计260万死产的12.2％。这表明尼日利亚仍然对全球死产负担作出了重大贡献。这项研究的目的是确定尼日利亚八家转诊医院的患病率，并确定死产的相关原因和因素。方法这是一项横断面研究，研究了六个综合医院（南部的4家，北部的2家，北部的两个教学医院）在6个月内的所有分娩情况。研究人群是研究期间在医院分娩的妇女。使用经过预先测试的研究方案来获得有关六个月内医院妊娠，活产和死产的临床数据。使用单变量，双变量和多元逻辑回归分析对数据进行集中分析。主要结局指标是医院的死产率（无论是整体还是整体）。结果医院有4416例单胞胎和175例死胎，平均死胎率为每1000例39.6（范围：12.7至67.3 / 1000例）。产前（浸软）占死胎的22.3％；47.4％为产时（死产）；而30.3％为未分类。急性缺氧占死产的32.6％。其他原因包括孕产妇高血压疾病（6.9％）和无法解释的产内原因（5.7％）。调整混杂变量后，死产的重要预测指标是转诊状况，产次，死产的过往经历，出生体重，分娩时的胎龄和分娩方式。结论我们得出的结论是，尼日利亚转诊医院的死产率很高，这主要是由于患者的相关因素和怀孕并发症的高发生率。通过改善患者的教育水平和紧急产科护理来解决这些问题的努力将降低该国的死产率。试用注册试用注册号NCTR91540209。尼日利亚临床试验注册处。http://www.nctr.nhrec.net/于2016年4月14日注册。试用注册试用注册号NCTR91540209。尼日利亚临床试验注册处。http://www.nctr.nhrec.net/于2016年4月14日注册。试用注册试用注册号NCTR91540209。尼日利亚临床试验注册处。http://www.nctr.nhrec.net/于2016年4月14日注册。