BACKGROUND To establish the changes in perinatal morbidity and mortality in twin pregnancies in Finland, a retrospective register research was conducted. Our extensive data from a 28-year study period provide important information on the outcome of twin pregnancies in Finland that has previously not been reported to this extent. METHODS All 23,498 twin pregnancies with 46,996 children born in Finland during 1987-2014 were included in the study. Data were gathered from the Medical Birth Register and the Hospital Discharge Register (Finnish Institute for Health and Welfare, Finland) regarding perinatal mortality (PNM) and morbidity. For statistical analysis, binomial regression analysis and crosstabs were performed. The results are expressed in means, percentages and ranges with comparison to singletons when appropriate. Odds ratios from binomial regression analysis are reported. A p-value <0.05 was considered statistically significant. RESULTS There were 46,363 liveborn and 633 stillborn twins in Finland during 1987-2014. Perinatal mortality decreased markedly, from 45.1 to 6.5 per 1000 for twin A and from 54.1 to 11.9 per 1000 for twin B during the study period. Yet, the PNM difference between twin A and B remained. Early neonatal mortality did not differ between twins, but has decreased in both. Asphyxia, respiratory distress syndrome, need for antibiotics and Neonatal Intensive Care Unit (NICU) stay were markedly more common in twin B. CONCLUSIONS In Finland, PNM and early neonatal mortality in twins decreased significantly during 1987-2014 and are nowadays very low. However, twin B still faces more complications. The outline provided may be used to further improve the monitoring and thus perinatal outcome of twins, especially twin B.

中文翻译：

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芬兰双胞胎的围产期结局：一项回顾性研究。


背景 为了确定芬兰双胎妊娠围产期发病率和死亡率的变化，进行了一项回顾性登记研究。我们在 28 年研究期间收集的大量数据提供了有关芬兰双胎妊娠结果的重要信息，而此前从未有过如此程度的报道。方法 本研究纳入了 1987 年至 2014 年间在芬兰出生的所有 23,498 名双胞胎孕妇和 46,996 名婴儿。有关围产期死亡率 (PNM) 和发病率的数据来自医学出生登记处和医院出院登记处（芬兰健康与福利研究所，芬兰）。对于统计分析，进行二项式回归分析和交叉表。结果以平均值、百分比和范围表示，并在适当时与单例进行比较。报告二项式回归分析的优势比。 p 值<0.05 被认为具有统计显着性。结果 1987 年至 2014 年间，芬兰有 46,363 名活产双胞胎和 633 名死产双胞胎。在研究期间，双胞胎 A 的围产期死亡率显着下降，从每 1000 人 45.1 降至 6.5，B 双胞胎从每 1000 人 54.1 降至 11.9。然而，双胞胎 A 和 B 之间的 PNM 差异仍然存在。早期新生儿死亡率在双胞胎之间没有差异，但两者均有所下降。窒息、呼吸窘迫综合征、需要抗生素和新生儿重症监护病房 (NICU) 住院在双胞胎 B 中明显更为常见。 结论 在芬兰，双胞胎的 PNM 和早期新生儿死亡率在 1987 年至 2014 年期间显着下降，目前非常低。然而，双胞胎B仍然面临着更多的并发症。所提供的大纲可用于进一步改善监测，从而改善双胞胎（尤其是 B 型双胞胎）的围产期结局。