BACKGROUND Gorham-Stout disease, also known as vanishing bone disease, idiopathic massive osteolysis, is a rare entity of unknown etiopathology. This disease is characterized by destruction of osseous matrix and proliferation of lymphatic vascular structures and associated with massive regional osteolysis. It has a variable clinical presentation and is commonly considered as a benign disease with a progressive tendency and an unpredictable prognosis. The diagnosis is made by exclusion and based on combination with histological, radiological, and clinical features. Despite that several therapeutic options have shown certain efficacy, the effective treatment still remains controversial and there is no standard treatment to be recommended. CASE PRESENTATION A previously healthy 40-year-old man presented with right lateral malleolus pain after an ankle sprain and was referred to our hospital. The radiographs indicated rapid massive bone destruction in the distal right lateral malleolus with an unclear margin. Based on the combination with histological, radiological, and clinical features, the diagnosis of Gorham-Stout disease was made. Considering that the residual function of malleolus had to be protected, prior bisphosphonate was used to control the progression of lesion, followed by surgical resection and biological reconstruction with autologous fibular bone grafting. The patient was followed up 8 years after surgery, he presented without progression and recurrence. CONCLUSIONS We depict a case of Gorham-Stout disease at the right lateral malleolus and was successfully controlled by medication and surgical intervention. Based on the prior effective medical treatment, resection with biological reconstruction is a useful approach to treat Graham-Stout disease in bone.

中文翻译：

---

踝关节的戈拉姆-斯托特病：罕见病例报告。

背景技术戈拉姆-斯托特氏病（Gorham-Stout disease），也称为消失性骨病，特发性大规模骨溶解，是病因学未知的罕见实体。这种疾病的特征是骨基质破坏和淋巴管血管结构增生，并伴有大量区域性骨溶解。它具有可变的临床表现，通常被认为是一种良性疾病，具有进行性趋势和不可预测的预后。诊断是通过排除并结合组织学，放射学和临床特征进行的。尽管有几种治疗方法已显示出一定的疗效，但有效的治疗方法仍存在争议，因此没有推荐的标准治疗方法。病例介绍一名先前健康的40岁男子在踝关节扭伤后出现右外踝疼痛，并被转诊到我们医院。X线片显示右外踝远端迅速大量骨破坏，边缘不清楚。基于组织学，放射学和临床特征的结合，对高汉姆-斯托特病进行了诊断。考虑到必须保护踝关节的残余功能，使用先前的双膦酸盐控制病变的进展，然后进行手术切除和自体腓骨植骨进行生物重建。术后8年对患者进行了随访，表现为无进展和复发。结论我们描述了一例右外踝Gorham-Stout病，并通过药物和外科手术成功控制。在先前有效的医学治疗的基础上，进行生物重建的切除术是治疗骨骼Graham-Stout疾病的有用方法。