BACKGROUND Inference of cancer-causing genes and their biological functions are crucial but challenging due to the heterogeneity of somatic mutations. The heterogeneity of somatic mutations reveals that only a handful of oncogenes mutate frequently and a number of cancer-causing genes mutate rarely. RESULTS We develop a Cytoscape app, named ZDOG, for visualization of the extent to which mutated genes may affect cancer pathways using the dominating tree model. The dominator tree model allows us to examine conveniently the positional importance of a gene in cancer signalling pathways. This tool facilitates the identification of mutated "master" regulators even with low mutation frequency in deregulated signalling pathways. CONCLUSIONS We have presented a model for facilitating the examination of the extent to which mutation in a gene may affect downstream components in a signalling pathway through its positional information. The model is implemented in a user-friendly Cytoscape app which will be freely available upon publication. AVAILABILITY Together with a user manual, the ZDOG app is freely available at GitHub (https://github.com/rudi2013/ZDOG). It is also available in the Cytoscape app store (http://apps.cytoscape.org/apps/ZDOG) and users can easily install it using the Cytoscape App Manager.

中文翻译：

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ZDOG：放大癌症路径中具有突变的主要基因。

背景技术由于体细胞突变的异质性，致癌基因及其生物学功能的推断是至关重要的，但具有挑战性。体细胞突变的异质性表明，只有少数致癌基因频繁突变，而许多致癌基因很少突变。结果我们开发了一个名为ZDOG的Cytoscape应用程序，用于使用优势树模型可视化突变基因在多大程度上影响癌症途径。优势树模型使我们可以方便地检查基因在癌症信号通路中的位置重要性。该工具即使在失调的信号通路中具有低突变频率，也有助于鉴定突变的“主”调节子。结论我们提出了一个模型，该模型有助于检查基因突变可能通过其位置信息影响信号传导途径下游成分的程度。该模型是在用户友好的Cytoscape应用中实现的，该应用将在发布时免费提供。可用性与用户手册一起，ZDOG应用程序可从GitHub（https://github.com/rudi2013/ZDOG）免费获得。Cytoscape应用程序商店（http://apps.cytoscape.org/apps/ZDOG）中也提供了该工具，用户可以使用Cytoscape App Manager轻松安装它。ZDOG应用程序可从GitHub（https://github.com/rudi2013/ZDOG）免费获得。Cytoscape应用程序商店（http://apps.cytoscape.org/apps/ZDOG）中也提供了该工具，用户可以使用Cytoscape App Manager轻松安装它。ZDOG应用程序可从GitHub（https://github.com/rudi2013/ZDOG）免费获得。Cytoscape应用程序商店（http://apps.cytoscape.org/apps/ZDOG）中也提供了该工具，用户可以使用Cytoscape App Manager轻松安装它。