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Cyclic nucleotides, gut physiology and inflammation.
The FEBS Journal ( IF 5.5 ) Pub Date : 2020-01-14 , DOI: 10.1111/febs.15198 Hari Prasad 1 , Avinash Ravindranath Shenoy 2 , Sandhya Srikant Visweswariah 1
The FEBS Journal ( IF 5.5 ) Pub Date : 2020-01-14 , DOI: 10.1111/febs.15198 Hari Prasad 1 , Avinash Ravindranath Shenoy 2 , Sandhya Srikant Visweswariah 1
Affiliation
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Misregulation of gut function and homeostasis impinges on the overall well-being of the entire organism. Diarrheal disease is the second leading cause of death in children under 5 years of age, and globally, 1.7 billion cases of childhood diarrhea are reported every year. Accompanying diarrheal episodes are a number of secondary effects in gut physiology and structure, such as erosion of the mucosal barrier that lines the gut, facilitating further inflammation of the gut in response to the normal microbiome. Here, we focus on pathogenic bacteria-mediated diarrhea, emphasizing the role of cyclic adenosine 3',5'-monophosphate and cyclic guanosine 3',5'-monophosphate in driving signaling outputs that result in the secretion of water and ions from the epithelial cells of the gut. We also speculate on how this aberrant efflux and influx of ions could modulate inflammasome signaling, and therefore cell survival and maintenance of gut architecture and function.
中文翻译：
环核苷酸，肠道生理学和炎症。
肠道功能和体内平衡的失调会影响整个生物体的整体健康。腹泻病是 5 岁以下儿童死亡的第二大原因，全球每年报告 17 亿例儿童腹泻病例。伴随腹泻发作的是对肠道生理和结构的许多次要影响，例如肠道粘膜屏障的侵蚀，促进肠道对正常微生物组的进一步炎症反应。在这里，我们专注于病原菌介导的腹泻，强调环腺苷 3',5'-单磷酸和环鸟苷 3',5'-单磷酸在驱动信号输出中的作用，从而导致上皮细胞分泌水和离子肠道细胞。
更新日期：2019-12-30
中文翻译：
环核苷酸，肠道生理学和炎症。
肠道功能和体内平衡的失调会影响整个生物体的整体健康。腹泻病是 5 岁以下儿童死亡的第二大原因，全球每年报告 17 亿例儿童腹泻病例。伴随腹泻发作的是对肠道生理和结构的许多次要影响，例如肠道粘膜屏障的侵蚀，促进肠道对正常微生物组的进一步炎症反应。在这里，我们专注于病原菌介导的腹泻，强调环腺苷 3',5'-单磷酸和环鸟苷 3',5'-单磷酸在驱动信号输出中的作用，从而导致上皮细胞分泌水和离子肠道细胞。
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