N‐Heterocyclic Carbene Catalyzed [3+2] Cycloaddition of Enals with β,γ ‐Unsaturated α ‐Ketimino Esters for the Synthesis of Multisubstituted Cyclopentanone,Advanced Synthesis & Catalysis

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N‐Heterocyclic Carbene Catalyzed [3+2] Cycloaddition of Enals with β,γ ‐Unsaturated α ‐Ketimino Esters for the Synthesis of Multisubstituted Cyclopentanone
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-01-16 , DOI: 10.1002/adsc.201901144
Xiao‐Qian Shi ₁ , Meng‐Die Dong ₁ , Xiao‐Yong Duan _{1,

2} , Teng‐Liang Cao ₁ , Jing Qi _{1,

2}

Affiliation

A convenient strategy of N‐heterocyclic carbene catalyzed [3+2] cycloaddition of enals with β,γ‐unsaturated α‐ketimino esters is developed. This effective protocol features mild reaction conditions and broad substrate scope, which enables the rapid assembly of various benzoxazinone derived cyclopentanone scaffolds in good to high yields with excellent diastereoselectivities.

中文翻译：

N-杂环碳烯催化的[3 + 2]环烯与β，γ-不饱和α-Ketimino酯的环加成反应，用于合成多取代的环戊酮

提出了一种方便的策略，该方法是N杂环卡宾通过β，γ-不饱和α-酮亚胺酸酯催化烯类的[3 + 2]环加成反应。该有效方案具有温和的反应条件和广泛的底物范围，从而能够以优异的非对映选择性快速组装各种苯并恶嗪酮衍生的环戊酮支架，且产率高至高。

更新日期：2020-01-17

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