Orthogonal Genetic Systems.,ChemBioChem

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Orthogonal Genetic Systems.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-02-06 , DOI: 10.1002/cbic.201900725
John C Chaput ₁ , Piet Herdewijn ₂ , Marcel Hollenstein ₃

Affiliation

Xenobiology is an emerging area of synthetic biology that aims to safeguard genetically engineered cells by storing synthetic biology information in xeno-nucleic acid polymers (XNAs). Critical to the success of this effort is the need to establish cellular systems that can maintain an XNA chromosome in actively dividing cells. This viewpoint discusses the structural parameters of the nucleic acid backbone that should be considered when designing an orthogonal genetic system that can replicate without interference from the endogenous genome. In addition to practical value, these studies have the potential to provide new fundamental insight into the structure and function properties of unnatural nucleic acid polymers.

中文翻译：

正交遗传系统。

异种生物学是合成生物学的新兴领域，旨在通过将合成生物学信息存储在异种核酸聚合物（XNA）中来保护基因工程细胞。这项工作能否成功的关键是，需要建立能够在活跃分裂细胞中维持XNA染色体的细胞系统。该观点讨论了设计可复制而不受内源基因组干扰的正交遗传系统时应考虑的核酸骨架的结构参数。除了实用价值外，这些研究还可能为非天然核酸聚合物的结构和功能特性提供新的基础见解。

更新日期：2019-12-30

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