L-ferritin: A theranostic agent of natural origin for MRI visualization and treatment of breast cancer.,Journal of Controlled Release

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L-ferritin: A theranostic agent of natural origin for MRI visualization and treatment of breast cancer.
Journal of Controlled Release ( IF 10.5 ) Pub Date : 2019-12-31 , DOI: 10.1016/j.jconrel.2019.12.051
Valeria Bitonto ₁ , Diego Alberti ₁ , Roberto Ruiu ₁ , Silvio Aime ₁ , Simonetta Geninatti Crich ₁ , Juan Carlos Cutrin ₁

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The altered regulation of iron uptake and metabolism in cancerous cells, along with the potential of this metal to cause oxidative stress and cell death, makes iron overload an attractive therapeutic strategy for cancer treatment. In this study, the selective uptake of native HoS-ferritin (Horse-Spleen Ferritin) was assessed in TS/A breast cancer cells and compared with benign cystadenoma NMuMG. The higher expression of L-ferritin receptor SCARA5 led to an enhanced uptake in TS/A that is detected by the generation of a negative contrast in the corresponding MR images. The toxicity of HoS-ferritin toward TS/A cells has been investigated in detail in vitro, showing that cellular vitality is inversely related to the amount of internalized iron content. Finally, biodistribution and therapeutic efficacy of HoS-ferritin have been shown for the first time in vivo on a orthotopic breast cancer mice model, suggesting that iron overdose delivered by the HoS-ferritin can trigger selective mechanisms of regulated cell death.

中文翻译：

L-铁蛋白：天然来源的治疗诊断剂，用于MRI可视化和治疗乳腺癌。

癌细胞中铁摄取和代谢的调节改变，以及这种金属引起氧化应激和细胞死亡的潜力，使铁超载成为一种有吸引力的癌症治疗策略。在这项研究中，评估了在TS / A乳腺癌细胞中对天然HoS-铁蛋白（马脾铁蛋白）的选择性摄取，并将其与良性膀胱腺瘤NMuMG进行了比较。L-铁蛋白受体SCARA5的较高表达导致TS / A摄取增加，这可通过在相应的MR图像中产生负对比度来检测。体外已详细研究了HoS-铁蛋白对TS / A细胞的毒性，表明细胞活力与内在铁含量成反比。最后，

更新日期：2019-12-31

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