Light and sound to trigger the Pandora's box against breast cancer: A combination strategy of sonodynamic, photodynamic and photothermal therapies.,Biomaterials

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Light and sound to trigger the Pandora's box against breast cancer: A combination strategy of sonodynamic, photodynamic and photothermal therapies.
Biomaterials ( IF 12.8 ) Pub Date : 2019-12-31 , DOI: 10.1016/j.biomaterials.2019.119685
Zhe Liu ₁ , Jiaping Li ₂ , Waner Chen ₃ , Lin Liu ₄ , Fangfang Yu ₅

Affiliation

An ideal strategy to eliminate cancerous lesions is to implement light/sound as the most natural approaches, so that a non-invasive treatment can be realized to decrease the mortality and enhance the health quality of patients. Herein, the composite peptide amphiphile-ICG nanomicelles were fabricated via the self-assembly of engineered peptide amphiphiles in corporation with a sono-/photosensitizer of ICG encapsulation. As a multifunctional nanoagent, they were utilized to the SDT-PDT-PTT combination therapy, which proved prevailing efficiency for in-vitro cell targeting and in-vivo tumor treatments against breast tumors. The immune response activation mechanism on tumor inhibition and lesion necrosis were explained by routine blood examinations, pro-inflammatory cytokines analysis and histological HE-TUNEL stainings. In summary, this non-invasive strategy paves a promising way to the combination therapy against cancers, and it will be an extremely attracting approach for neuro-carcinomas and cerebral diseases treatments readily triggered by light/sound as an external controllable source.

中文翻译：

光和声音触发潘多拉魔盒抗击乳腺癌：声动力，光动力和光热疗法的组合策略。

消除癌性病变的理想策略是采用声音/声音作为最自然的方法，以便可以实现无创治疗以降低死亡率并提高患者的健康水平。本文中，复合肽两亲物-ICG纳米胶束是通过工程化肽两亲物的自组装与ICG包封的声光/光敏剂一起制造的。作为多功能纳米剂，它们被用于SDT-PDT-PTT联合治疗，证明了针对乳腺肿瘤的体外细胞靶向和体内肿瘤治疗的普遍有效性。通过常规血液检查，促炎细胞因子分析和组织学HE-TUNEL染色解释了对肿瘤抑制和病变坏死的免疫应答激活机制。总之，

更新日期：2019-12-31

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