To the Editor We have 4 concerns about the article and editorial on the association between maternal fluoride exposure during pregnancy and offspring IQ.^1,2 First, there was no significant IQ difference between children from fluoridated and nonfluoridated communities and no overall association with maternal urinary fluoride (MUF_SG). The authors did not mention this and instead emphasized the significant sex interaction, where the association appeared for boys but not girls. No theoretical rationale for this test was provided; in the absence of a study preregistration, we cannot know whether it was planned a priori. If not, the false-positive probability increases because there are many potential subgroups that might show the result by chance. Importantly, the result was contradicted by the self-report analysis, which showed an overall effect but no sex interaction, casting doubt on the latter’s validity.

致编辑对于这篇文章和社论，我们有4个关注点，即孕期孕产妇氟暴露与后代智商之间的关系。^{1 ，2}首先，没有显著孩子智商之间的氟气和nonfluoridated社区和产妇尿氟总体上没有关联性（MUF _SG）。作者没有提及这一点，而是强调了重要的性交往，这种交往只出现在男孩身上，而没有出现在女孩身上。没有提供该测试的理论依据；在没有进行研究预注册的情况下，我们无法知道是否事先计划了该研究。如果不是，则假阳性概率会增加，因为可能有很多潜在的子组可能会偶然显示结果。重要的是，该结果与自我报告分析相矛盾，自我报告分析显示出总体效果，但没有性别互动，这使后者的有效性受到怀疑。