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Design and Synthesis of ZnII -Coordination Polymers Anchored with NSAIDs: Metallovesicle Formation and Multi-drug Delivery.
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2019-12-30 , DOI: 10.1002/asia.201901664 Sourabh Bera 1 , Abhinanda Chowdhury 1 , Koushik Sarkar 1 , Parthasarathi Dastidar 1
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2019-12-30 , DOI: 10.1002/asia.201901664 Sourabh Bera 1 , Abhinanda Chowdhury 1 , Koushik Sarkar 1 , Parthasarathi Dastidar 1
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A series of coordination polymers synthesized from a bis-pyridyl linker, namely 4,4'-azopyridine (L), selected non-steroidal-anti-inflammatory drugs (NSAIDs), namely diclofenac (Dic), ibuprofen (Ibu), flurbiprofen (Flu), mefenamic acid (Mefe), and naproxen (Nap), and Zn(NO3 )2 were characterized by single crystal X-ray diffraction. One of the coordination polymers, namely CP3 derived from Flu, was able to form metallovesicles in DMSO, DMSO/H2 O and DMSO/DMEM (biological media) as revealed by TEM, AFM and DLS. Metallovesicle formation by CP3 was further supported by loading a fluorescent dye, namely calcein, as well as an anti-cancer drug, doxorubicin hydrochloride (DOX), as revealed by UV-vis and emission spectra, and fluorescence microscopy. DOX-loaded metallovesicles of CP3 (DOX@CP3-vesicle) could be delivered in vitro to a highly aggressive human breast cancer cell line, namely MDA-MB-231, as revealed by MTT and cell migration assays, and also cell imaging performed under laser scanning confocal microscope (LSCM). Thus, a proof of concept for developing a multi-drug delivery system derived from a metallovesicle for delivering an anti-cancer drug to cancer cells is demonstrated for the first time.
中文翻译：
NSAIDs锚定的ZnII配位聚合物的设计与合成：金属膜的形成和多种药物的递送。
由双吡啶基连接体（即4,4'-偶氮吡啶（L），选定的非甾体抗炎药（NSAID），双氯芬酸（Dic），布洛芬（Ibu），氟比洛芬（通过单晶X射线衍射表征了吗啡，甲芬那酸（Mefe）和萘普生（Nap）和Zn（NO3）2的特征。TEM，AFM和DLS揭示，其中一种配位聚合物，即来自Flu的CP3，能够在DMSO，DMSO / H2 O和DMSO / DMEM（生物介质）中形成金属lovesicles。通过紫外荧光可见光谱和发射光谱以及荧光显微镜观察，通过负载荧光染料即钙黄绿素以及抗癌药盐酸阿霉素，进一步支持了CP3形成的金属爱情小说。如MTT和细胞迁移分析所揭示，可以将DOX负载的CP3的金属爱情小体（DOX @ CP3-vesicle）体外递送至高度侵袭性的人类乳腺癌细胞系MDA-MB-231，并在激光扫描共聚焦显微镜（LSCM）。因此，首次证明了开发用于衍生自金属小药丸的多药递送系统以将抗癌药递送至癌细胞的概念证明。
更新日期：2020-01-23
中文翻译：
NSAIDs锚定的ZnII配位聚合物的设计与合成：金属膜的形成和多种药物的递送。
由双吡啶基连接体（即4,4'-偶氮吡啶（L），选定的非甾体抗炎药（NSAID），双氯芬酸（Dic），布洛芬（Ibu），氟比洛芬（通过单晶X射线衍射表征了吗啡，甲芬那酸（Mefe）和萘普生（Nap）和Zn（NO3）2的特征。TEM，AFM和DLS揭示，其中一种配位聚合物，即来自Flu的CP3，能够在DMSO，DMSO / H2 O和DMSO / DMEM（生物介质）中形成金属lovesicles。通过紫外荧光可见光谱和发射光谱以及荧光显微镜观察，通过负载荧光染料即钙黄绿素以及抗癌药盐酸阿霉素，进一步支持了CP3形成的金属爱情小说。如MTT和细胞迁移分析所揭示，可以将DOX负载的CP3的金属爱情小体（DOX @ CP3-vesicle）体外递送至高度侵袭性的人类乳腺癌细胞系MDA-MB-231，并在激光扫描共聚焦显微镜（LSCM）。因此，首次证明了开发用于衍生自金属小药丸的多药递送系统以将抗癌药递送至癌细胞的概念证明。
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